RT info:eu-repo/semantics/article
T1 The Breast Cancer Resistance Protein (BCRP/ABCG2) influences the levels of enterolignans and their metabolites in  plasma, milk and mammary gland
A1 García Mateos, Dafne
A1 García-Villalba, Rocío
A1 Marañón, José Ángel
A1 Espín, Juan Carlos
A1 Merino Peláez, Gracia
A1 Álvarez de Felipe, Ana Isabel
A2 Fisiologia
K1 Sanidad animal
K1 Veterinaria
K1 Enterolactone
K1 Enterodiol
K1 ABCG2,
K1 Milk
K1 Mammary gland
K1 Gut microbiota
AB Lignans are phytoestrogens widely used in dietary supplements and functional foods. After oralingestion, these polyphenols are metabolized to enterolignans, the main gut microbiota-derivedmetabolites with weak estrogenic/anti-estrogenic activities. The ABCG2 transporter is highlyexpressed in the mammary gland and could be responsible for enterolignan accumulation. Weaimed here at evaluating the levels of enterolignans and their conjugates in plasma, milk andmammary tissue from wild-type and knockout Abcg2-/- female mice after a lignan-enriched dietfor one week. In vitro transepithelial transport of enterolignans was also assayed with ABCG2-transduced cells. Enterolactone and enterodiol levels were higher in plasma and lower in milkfrom Abcg2-/- compared with wild-type mice. Both enterolactone and enterodiol wereaccumulated in the mammary gland but with significant differences only for enterolactone. Ourresults suggest that ABCG2 may be determinant for plasma and milk levels of enterolignanswhose accumulation could exert chemopreventive effects against breast cancer
PB Elsevier
YR 2017
FD 2017-10-10
LK http://hdl.handle.net/10612/6863
UL http://hdl.handle.net/10612/6863
NO Journal of Functional Foods, 2017, n. 35
NO P. 648-654
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 19-abr-2024