RT info:eu-repo/semantics/conferenceObject
T1 Variant discovery in genes identified as differentially expressed genes between the abomasal lymph node transcriptome of resistant and susceptible adult sheep to teladorsagia circumcincta infection
A1 Chitneedi, Praveen K.
A1 Suárez Vega, Aroa
A1 Martínez Valladares, María
A1 Arranz Santos, Juan José
A1 Gutiérrez Gil, Beatriz
A2 Producción Animal
K1 Producción animal
K1 Teladorsagia circumcincta
K1 Ganado ovino
AB Gastrointestinal nematode infections are one of the major health issues facing grazingsheep populations and it incurs on major economic losses for sheep breeders. Theresistance/susceptibility trait appears to be a highly complex trait (Behnke et al. 2003;Dominik 2005). In sheep resistance to nematode infection shows a moderate level ofheritability (range 0.3-0.6) (Stear et al. 2001). Several QTL mapping studies have tried toidentify genomic regions and mutations that influence resistance to nematode infection(Atlija et al. 2016; Coltman et al. 2001; Gutiérrez-Gil et al. 2009; Sayers et al. 2005), althoughthe detection of causal mutations for this trait is still a challenge for the research community.The recently available RNA-seq technology provides the opportunity to extract highthroughputtranscriptome data from a specific tissue to perform gene quantification,differential gene expression and detection of variants (SNPs and indels), which could beassessed as potential causal mutations (Hudson, Dalrymple, and Reverter 2012). Aprevious study of our research group has identified a list of 106 differential expression genes(DEGs) based on RNA-Seq dataset obtained from the abomasal lymph nodes of 12 adultsheep, previously classified as resistant or susceptible to GIN infection based on an artificialinfection with T. circumcincta larvae Chitneedi et al. (2018). In the present study we presenta detailed study of the variants mapping within the list of DEGs previously reported in thatstudy. Thus, the present study provides a list of functionally relevant variants that couldunderlie the genetic control of resistance/susceptibility to T. circumcincta in adult sheep. Financiado por la Junta de Castilla y León (Conserjería de Educación) y Fondo Social Europeo (Ref. LE248U14). Ejecución: Universidad de León. Dpto. Producción Animal. Investigador Principal: Dr. Beatriz Gutierrez Gil
SN G
YR 2018
FD 2018-07-02
LK http://hdl.handle.net/10612/8285
UL http://hdl.handle.net/10612/8285
NO XIX Reunión Nacional de Mejora Genetica Animal, 14-15 de junio, 2018, León
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 27-abr-2024