RT info:eu-repo/semantics/bookPart
T1 Beneficial effect of physical exercise on telomere length and aging, and genetics of aging-associated noncommunicable diseases
A1 Estébanez González, Brisamar
A1 Rodríguez Miguélez, Paula
A1 Fernández Gonzalo, Rodrigo
A1 González Gallego, Javier
A1 Cuevas González, María José
A2 Fisiologia
K1 Fisiología
K1 Age-related diseases
K1 Aging, exercise
K1 Inflammation
K1 Oxidative stress
K1 Satellite cells
K1 Telomerase
K1 Telomere shortening
K1 2411 Fisiología Humana
K1 2411.06 Fisiología del Ejercicio
K1 32 Ciencias Médicas
AB [EN] As organisms advance in age, telomere shortening occurs. Among the different causes involved in this process, lifestyle factors and certain alterations at cellular level, both related to cellular senescence process and organism aging, have been identified as responsible for this decrease in telomere length (TL). Cellular alterations that have been shown to play a predominant role in telomere shortening are telomerase activity, oxidative stress and inflammation. Telomere shortening, whether caused by or resulting from cellular senescence, has been related to the presence of age-related diseases, such as dementia, diabetes mellitus, chronic cardiovascular and pulmonary disease or skin disorders. The level of physical activity is one of life factors closely related to TL. Thus, regular physical activity promotes telomerase activity, decreases oxidative stress and inflammation, and increases the number of satellite cells, exerting, ultimately, a protective effect on telomeres.
PB Academic Press (ELSEVIER)
SN 9780128161937
LK https://hdl.handle.net/10612/17862
UL https://hdl.handle.net/10612/17862
NO Estébanez, B., Rodriguez-Miguelez, P., Fernandez-Gonzalo, R., González-Gallego, J., & Cuevas, M. J. (2019). Beneficial effect of physical exercise on telomere length and aging, and genetics of aging-associated noncommunicable diseases. En Sports, Exercise, and Nutritional Genomics: Current Status and Future Directions (pp. 509-538). Elsevier. https://doi.org/10.1016/B978-0-12-816193-7.00022-1
DS BULERIA. Repositorio Institucional de la Universidad de León
RD Jul 6, 2024