RT info:eu-repo/semantics/article
T1 Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study
T2 Potencial inflamatorio de la dieta y densidad mineral ósea en una población mediterránea senior: un análisis transversal del estudio PREDIMED-Plus
A1 García-Gavilán, Jesús F.
A1 Paz-Graniel, Indira
A1 Babio, Nancy
A1 Romaguera, Dora
A1 Martínez, Jose Alfredo
A1 Martin, Vicente
A1 Martínez, María Ángeles
A1 Konieczna, Jadwiga
A1 Ruiz-Canela, Miguel
A1 de Paz Fernandez, José Antonio
A1 Goday, Albert
A1 Martínez-González, Miguel Ángel
A1 Bulló, Mònica
A1 Salas-Salvadó, Jordi
A2 Medicina Preventiva
K1 Medicina. Salud
K1 Bone mineral density
K1 Diet
K1 Inflammation
K1 Osteoporosis
K1 32 Ciencias Médicas
AB [EN] Purpose: Inflammation could play a key role in tissue damage and bone metabolism. The modified dietary inflammatory score (M-DIS) is a validated tool to estimate the inflammatory potential of the diet. In the present study, we evaluate the associations between the M-DIS and bone mineral density (BMD) in a senior Mediterranean population with overweight/obesity and metabolic syndrome. Methods: Baseline cross-sectional association between the M-DIS and bone mineral density was assessed in 1134 participants of the multicenter PREDIMED-Plus trial (aged 55-75 with overweight/obesity and metabolic syndrome). BMD was measured using Dual-energy X-ray Absorptiometry scans and participants answered a food frequency questionnaire to determine the M-DIS. BMD was categorized as low BMD when T score was equal or lower than -1 and normal BMD in another case. Associations between BMD and M-DIS were evaluated by using linear and logistic regressions adjusted by other co-variates. Results: Participants in the top tertile of the M-DIS had a lower BMD at total femur [β (95% CI) - 0.02 (- 0.04, - 0.01)], trochanter areas [β (95% CI) - 0.03 (- 0.05, - 0.01)] and lumbar spine area [β (95% CI) - 0.03 (- 0.07, 0.01)] (but in the last case, measures were less precise and hence not statistically significant) compared to those in the lower M-DIS tertile. Multiple logistic regression analyses showed that the odds of the total femur and femoral trochanter osteopenia/osteoporosis were higher in participants in the top tertile compared to those in the lowest tertile of M-DIS [OR (95% CI) 1.71 (1.12, 2.64), P for trend 0.015; 2.02 (1.29, 3.21), P for trend 0.002, respectively]. Conclusion: A high pro-inflammatory diet, measured by the M-DIS, is associated with lower BMD in a senior Mediterranean population with metabolic syndrome.
PB Springer
SN 1436-6207
LK https://hdl.handle.net/10612/18231
UL https://hdl.handle.net/10612/18231
NO García-Gavilán, J. F., Paz-Graniel, I., Babio, N., Romaguera, D., Martínez, J. A., Martin, V., Martínez, M. Á., Konieczna, J., Ruiz-Canela, M., de Paz Fernandez, J. A., Goday, A., Martínez-González, M. Á., Bulló, M., & Salas-Salvadó, J. (2022). Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study. European Journal of Nutrition, 61(3), 1445-1455. https://doi.org/10.1007/S00394-021-02751-5
DS BULERIA. Repositorio Institucional de la Universidad de León
RD Jul 7, 2024