RT info:eu-repo/semantics/article
T1 The thymus is required for the ability of FTY720 to prolong skin allograft survival across different histocompatibility MHC barriers
A1 Río González, María Luisa del
A1 Pabst, Oliver
A1 Ramírez, Pablo
A1 Penuelas Rivas, Giovanna
A1 Förster, Reinhold
A1 Rodríguez Barbosa, José Ignacio
A2 Sanidad Animal
K1 Inmunología
K1 Sanidad animal
K1 FTY720
K1 Major histocompatibility complex (MHC) barriers
K1 Skin transplantation
K1 Thymus
K1 2412 Inmunología
AB [EN] The immunosuppressive effect of FTY720 is associated with the reversible sequestration of lymphocytes from the blood and the spleen into secondary lymphoid organs and reduced egress of mature thymocytes from the thymus. This work was designed to dissect the differential effect of FTY720 on CD4 and CD8 T cell-mediated mechanisms of skin graft rejection in the presence (euthymic) or absence (thymectomized) of thymic output. To that end, untreated and FTY720-treated euthymic (Euthy) and thymectomized (ATX) mice received skin allografts across a full, class II or class I major histocompatibility complex (MHC) mismatched (MM) barriers and graft survival was monitored. We demonstrate that a short course of FTY720 treatment significantly augments the survival of full, class I and class II MHC MM skin grafts compared to the nontreated controls. Interestingly, FTY720-treated Euthy recipients showed a significantly prolonged skin allograft survival compared to FTY720-treated ATX mice. These results together show that FTY720 impairs both CD4 and CD8 T cell-mediated mechanisms of rejection and, more importantly, the presence of the thymus is necessary for the ability of FTY720 to modulate skin allograft rejection across different histocompatibility MHC barriers. © 2007 The Authors.
PB Frontiers Media
SN 0934-0874
LK https://hdl.handle.net/10612/19931
UL https://hdl.handle.net/10612/19931
NO Del Río, M. L., Pabst, O., Ramírez, P., Penuelas Rivas, G., Förster, R., & Rodríguez Barbosa, J.-I. (2007). The thymus is required for the ability of FTY720 to prolong skin allograft survival across different histocompatibility MHC barriers. Transplant International, 20(10), 895-903. https://doi.org/10.1111/J.1432-2277.2007.00539.X
NO © 2007 The Authors
DS BULERIA. Repositorio Institucional de la Universidad de León
RD Jul 7, 2024