RT info:eu-repo/semantics/article
T1 PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation
A1 Río González, María Luisa del
A1 Buhler, Leo
A1 Gibbons, Carrie
A1 Tian, Jiong
A1 Rodríguez Barbosa, José Ignacio
A2 Inmunologia
K1 Inmunología
K1 Sanidad animal
K1 Antigen-presenting cells
K1 BTLA
K1 CD160
K1 Co-inhibition
K1 Co-stimulation
K1 HVEM
K1 PD-1
K1 PD-L1
K1 PD-L2
K1 Peripheral tolerance
K1 T cells
K1 Transplantation
K1 3109.03 Inmunología
AB [EN] Transplantation of cells, tissues and vascularized solid organs is a successful therapeutic intervention for many end-stage chronic diseases. The combination of co-stimulatory blockade with the delivery of negative signals to T cells through co-inhibitory receptors would provide a robust approach to modulating T-cell receptor signaling and improving alloantigen-specific control of transplant rejection. This approach based on fundamental knowledge of APC/T-cell interactions may complement conventional therapies in the near future to reinforce long-term allograft survival, and permit minimal immunosuppression. The focus of this review was primarily on two major co-inhibitory signaling pathways, namely PD-1/PD-L1/PD-L2 and BTLA/CD160/HVEM/LIGHT that have been thoroughly characterized in murine models of transplantation using genetically modified mice, specific monoclonal antibodies and fusion proteins
PB Frontiers Media
SN 0934-0874
LK https://hdl.handle.net/10612/20293
UL https://hdl.handle.net/10612/20293
NO del Río, M. L., Buhler, L., Gibbons, C., Tian, J., & Rodríguez Barbosa, J. I. (2008). PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transplant international : official journal of the European Society for Organ Transplantation, 21(11), 1015–1028. https://doi.org/10.1111/j.1432-2277.2008.00726.x
DS BULERIA. Repositorio Institucional de la Universidad de León
RD Jul 6, 2024