RT info:eu-repo/semantics/article
T1 The pharmacokinetics and metabolism of ivermectin in domestic animal species
A1 González, Aranzazu
A1 Sahagún , Ana M.
A1 Diez Liébana, María José
A1 Fernández, Nélida
A1 Sierra Vega, Matilde
A1 García, Juan J.
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Zoología
K1 Ivermectin
K1 Pharmacokinetics
K1 Animal species
K1 Absorption
K1 Distribution
K1 Metabolism
K1 Excretion
K1 Cattle
K1 Sheep
K1 Goat
K1 Pig
K1 Dog
K1 Review
AB The pharmacokinetic properties of drugs are closely related to their pharmacological efficacy. The kinetics of ivermectin are characterised,in general terms, by a slow absorption process, a broad distribution in the organism, low metabolism, and slow excretion. Thekinetics vary according to the route of administration, formulation, animal species, body condition, age, and physiological status, all ofwhich contribute to differences in drug efficacy. Characterisation of ivermectin kinetics can be used to predict and optimise the value ofthe parasiticide effects and to design programmes for parasite control. This article reviews the pharmacokinetics of ivermectin in severaldomestic animal species.
PB Elsevier
YR 2015
FD 2015-08-19
LK http://hdl.handle.net/10612/4527
UL http://hdl.handle.net/10612/4527
NO The Veterinary Journal, 2009, n. 179
NO P. 25-37
DS BULERIA. Repositorio Institucional de la Universidad de León
RD Jul 6, 2024