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Título
Efficacy of heat-inactivated Mycobacterium bovis vaccine delivered to European badgers (Meles meles) through edible bait
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Heliyon
Número de la revista
9
Datos de la obra
Juste, R. A., Blanco-Vázquez, C., Barral, M., Prieto, J. M., Varela-Castro, L., Lesellier, S., Dave, D., Sevilla, I. A., Martín Ezquerra, A. B., Adriaensen, H., Herrero-García, G., Garrido, J. M., Casais, R., y Balseiro, A. (2023). Efficacy of heat-inactivated Mycobacterium bovis vaccine delivered to European badgers (Meles meles) through edible bait. Heliyon, 9(9), e19349. https://doi.org/10.1016/j.heliyon.2023.e19349
Editor
Elsevier
Fecha
2023
ISSN
2405-8440
Resumo
[EN] Badgers (Meles meles) are a major tuberculosis (TB) reservoir in Europe, with the potential to transmit infection to cattle. Here we assessed whether a recently described oral tuberculosis vaccine based on heat-inactivated Mycobacterium bovis (HIMB), delivered as edible baits, can protect badgers from infection. Eight badgers were given individually five baits, each one consisting of a ball of peanut butter, natural peanut and oat flakes including a dose of the vaccine containing 5 × 107 colony-forming units. In parallel, a control group of seven badgers did not receive the vaccine. One month and a half later a second dose of the vaccine was offered to the vaccinated group. Ninety-four days after the second dose, all badgers were challenged with M. bovis (103 colony-forming units per animal) delivered endobronchially to the right middle lung lobe. Clinical, immunological, pathological and bacteriological variables were measured throughout the whole study to assess the efficacy of the vaccine. Two vaccinated animals showed high bacterial load of M. bovis and worsening of pathological lesions of TB. Conversely, the other six vaccinated animals showed slight improvement in bacterial load and pathology with respect to the control group. These results suggest that delivering the TB vaccine via food bait can partially protect wild badger populations, although vaccination can lead to either protection or tolerization, likely depending on the animal's immune status and general condition at the time of vaccination. Further optimization of the vaccination trial/strategy is needed to reduce the rate of tolerization, such as altering vaccine dose, number of doses, type of bait, use of adjuvants or route of administration.
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/RTI2018-096010-B-C21/ES/EL TEJON (MELES MELES) Y LA TUBERCULOSIS ANIMAL EN ESPAÑA: INTERACCION TEJON-BOVINO EN HOTSPOT AREAS Y MEDIDAS DE CONTROL DE LA ENFERMEDAD EN LA INTERFASE
- info:eu-repo/grantAgreement/Gobierno del Principado de Asturias/PCTI 2021–2023 (GRUPIN: IDI-2021-000102)
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