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Título
miR-29a is downregulated in progenies derived from chronically stressed males
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
International Journal of Molecular Sciences
Número de la revista
18
Cita Bibliográfica
Riesco, M. F., Valcarce, D. G., Sellés-Egea, A., Esteve-Codina, A., Herráez, M. P., & Robles, V. (2023). miR-29a Is Downregulated in Progenies Derived from Chronically Stressed Males. International journal of molecular sciences, 24(18), 14107. https://doi.org/10.3390/ijms241814107
Editorial
MDPI
Fecha
2023
Resumen
[EN] Recent research has provided compelling evidence demonstrating that paternal exposure
to different stressors can influence their offspring’s phenotypes. We hypothesized that paternal stress
can negatively impact the progeny, altering different miRs and triggering different physiological
alterations that could compromise offspring development. To investigate this, we exposed zebrafish
male siblings to a chronic stress protocol for 21 days. We performed RNA-sequencing (RNA-seq)
analyses to identify differentially expressed small noncoding RNAs in 7-day postfertilization (dpf)
larvae derived from paternally stressed males crossed with control females compared with the control
progeny. We found a single miRNA differentially expressed—miR-29a—which was validated in
larva and was also tested in the sperm, testicles, and brain of the stressed progenitors. We observed
a vertical transmission of chronic stress to the unexposed larvae, reporting novel consequences of
paternally inherited chronic stress at a molecular level. The deregulation of mi-R29a in those larvae
could affect relevant biological processes affecting development, morphogenesis, or neurogenesis,
among others. Additionally, these disruptions were associated with reduced rates of survival and
hatching in the affected offspring.
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/AEI/ Programa Estatal de Generación de Conocimiento y Fortalecimiento Científico y Tecnológico del Sistema de I+D+i/ PID2019-108509RB-I00/ES/ EL ESTRES EN LA REPRODUCCION DE PECES: TRANSMISION DE LOS EFECTOS NEGATIVOS A LA PROGENIE Y DESARROLLO DE NUEVAS TECNOLOGIAS PARA REVERTIRLOS
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