dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Fernández Riesco, Marta | |
dc.contributor.author | García Valcarce, David | |
dc.contributor.author | Martínez-Vázquez, Juan Manuel | |
dc.contributor.author | Robles Rodríguez, Vanesa | |
dc.contributor.other | Bioquimica y Biologia Molecular | es_ES |
dc.date | 2019 | |
dc.date.accessioned | 2023-12-13T07:59:56Z | |
dc.date.available | 2023-12-13T07:59:56Z | |
dc.identifier.citation | Riesco, M., Valcarce, D., Martínez Vázquez, J., Robles, V. (2019). Effect of low sperm quality on progeny: a study on zebrafish as model species. Scientific Reports. 9. 10.1038/s41598-019-47702-7 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/17466 | |
dc.description.abstract | [EN] Nowadays a decrease tendency in human sperm quality has been reported mainly in developed
countries. Reproductive technologies have been very valuable in achieving successful pregnancies
with low quality sperm samples. However, considering that spermatozoa molecular contribution is
increasingly important in recent studies, it is crucial to study whether fertilization with low sperm
quality could leave a molecular mark on progeny. This study explores the consequences that fertilization
with low sperm quality may have on progeny, using zebrafish as a model. Good and bad breeders were
established attending to sperm quality analyses and were individually tracked. Significant differences
in fertilization and malformation rates were obtained in progenies between high and low quality
sperm samples. Moreover an altered miR profile was found in the progenies of bad zebrafish breeders
(upregulation of miR-141 and miR -122 in 24 hpf embryos) and as a consequence, some of their targets
involved in male sex development such as dmrt1, suffered downregulation. Our results indicate
that fertilizing with high sperm quality samples becomes relevant from a new perspective: to avoid
molecular alterations in the progeny that could remain masked and therefore produce unexpected
consequences in it. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Biología | es_ES |
dc.subject.other | Progeny | es_ES |
dc.subject.other | Sperm | es_ES |
dc.subject.other | Zebrafish | es_ES |
dc.title | Effect of low sperm quality on progeny: a study on zebrafish as model species | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1038/s41598-019-47702-7 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/ Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/ AGL2015-68330-C2-1-R/ES/ MECANISMOS MOLECULARES SUBYACENTES AL FALLO REPRODUCTIVO EN SOLEA SENEGALENSIS: DESARROLLO DE NUEVAS ESTRATEGIAS Y TRATAMIENTOS PARA SOLVENTAR LA DISFUNCION REPRODUTIVA EN F1 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2045-2322 | |
dc.journal.title | Scientific Reports | es_ES |
dc.volume.number | 9 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 2415 Biología Molecular | es_ES |
dc.subject.unesco | 2401.19 Zoología Marina | es_ES |
dc.description.project | This work was supported by AGL2015 68330-C2-1-R project (MINECO/FEDER), PTA2016-11987-I contract (MINECO/FEDER) and AQUA-CIBUS international net 318RT0549 funded by CYTED (Programa Iberoamericano de Ciencia y Tecnologia para el Desarrollo) | es_ES |