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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Blanco Paniagua, Esther | |
dc.contributor.author | García Lino, Alba María | |
dc.contributor.author | Álvarez Fernández, Laura | |
dc.contributor.author | Álvarez de Felipe, Ana Isabel | |
dc.contributor.author | Merino Peláez, Gracia | |
dc.contributor.other | Fisiologia | es_ES |
dc.date | 2022 | |
dc.date.accessioned | 2024-01-09T11:46:35Z | |
dc.date.available | 2024-01-09T11:46:35Z | |
dc.identifier.citation | Blanco-Paniagua, E., Garcia-Lino, A. M., Alvarez-Fernández, L., Alvarez, A. I., & Merino, G. (2022). Ivermectin inhibits ovine ABCG2-mediated in vitro transport of meloxicam and reduces its secretion into milk in sheep. Research in Veterinary Science, 153, 88-91. https://doi.org/10.1016/J.RVSC.2022.10.019 | es_ES |
dc.identifier.issn | 0034-5288 | |
dc.identifier.uri | https://hdl.handle.net/10612/17562 | |
dc.description.abstract | [EN] The ATP-binding cassette transporter G2 (ABCG2) is an efflux protein involved in the bioavailability and secretion into milk of several compounds including anti inflammatory drugs. The aim of this work was to determine the effect in sheep of an ABCG2 inhibitor, such as the macrocyclic lactone ivermectin, on the secretion into milk of meloxicam, a non-steroidal anti-inflammatory drug widely used in veterinary medicine, and recently reported as an ABCG2 substrate. In vitro meloxicam transport assays in ovine ABCG2-transduced cells have shown that ivermectin is an efficient inhibitor of in vitro transport of meloxicam mediated by ovine ABCG2, with a 75% inhibition in the transport ratio (24.85 ± 4.62 in controls vs 6.31 ± 1.37 in presence of ivermectin). In addition, the role of ovine ABCG2 in secretion into milk of meloxicam was corroborated using Assaf lactating sheep coadministered with ivermectin. Animals were administered subcutaneously with meloxicam (0.5 mg/kg) with or without ivermectin (0.2 mg/kg). No difference in plasma pharmacokinetic parameters was found between treatments. In the case of milk, a significant reduction in the area under concentration-time curve (AUC) (3.92 ± 0.66 vs 2.26 ± 1.52 vs μg·h/mL) and the AUC milk-to-plasma ratio (0.17 ± 0.03 vs 0.09 ± 0.06) was reported for ivermectin-treated animals compared to controls. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Fisiología | es_ES |
dc.subject.other | ABCG2 | es_ES |
dc.subject.other | Ivermectin | es_ES |
dc.subject.other | Meloxicam | es_ES |
dc.subject.other | Milk | es_ES |
dc.subject.other | Sheep | es_ES |
dc.title | Ivermectin inhibits ovine ABCG2-mediated in vitro transport of meloxicam and reduces its secretion into milk in sheep | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1016/j.rvsc.2022.10.019 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/AGL2015-65626-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/RTI2018-100903-B-I00 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | es_ES |
dc.journal.title | Research in Veterinary Science | es_ES |
dc.volume.number | 153 | es_ES |
dc.page.initial | 88 | es_ES |
dc.page.final | 91 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/acceptedVersion | es_ES |
dc.subject.unesco | 3109.09 Fisiología | es_ES |
dc.description.project | This work was supported by the research projects AGL2015-65626-R (MCIN/AEI/10.13039/501100011033/FEDER” Una manera de hacer Europa”) and RTI2018-100903-B-I00 (MCIN/AEI/10.13039/501100011033/FEDER” Una manera de hacer Europa”); and by the predoctoral grants (FPU18/01559 grant to EBP, FPU19/04169 grant to LAF) from the Spanish Ministry of Education, Culture and Sport and BES-2016-077235 grant to AMGL (MCIN/AEI/10.13039/501100011033 y FSE ”El FSE invierte en tu futuro”). We are grateful to Prof. James McCue for assistance with language editing. | es_ES |
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