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Título
Healing of Chronic Wounds with Platelet-Derived Growth Factors from Single Donor Platelet-Rich Plasma following One Freeze-Thaw Cycle. A Cross-Sectional Study
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Journal of Clinical Medicine
Número de la revista
24
Datos de la obra
Vidán-Estévez, J., Sánchez-Herráez, S., Escalante-Barrigón, F., & Seco-Calvo, J. (2021). Healing of Chronic Wounds with Platelet-Derived Growth Factors from Single Donor Platelet-Rich Plasma following One Freeze-Thaw Cycle. A Cross-Sectional Study. Journal of clinical medicine, 10(24), 5762. https://doi.org/10.3390/jcm10245762
Editor
MDPI
Fecha
2021-12-09
Abstract
[EN]
Chronic non-healing wounds (CNHWs) may be associated with trauma or idiopathic in
nature and are difficult to treat. Our objective was to assess the use of platelet-derived growth factor
(PDGF) from single-donor platelets (al-PRP), using one freeze-thaw cycle, for treating CNHWs. We
conducted a cross-sectional study. A total of 23 CNHWs being treated with al-PRP. The al-PRP
treatment can be considered successful in well over half (n = 13, 56.5%) of the wounds. We found
that all the wounds treated for up to 7 weeks showed partial or complete healing, while those treated
for between 8 and 12 weeks did not show healing, healing again being successful in cases in which
treatment was extended to more than 13 weeks (85.7%). Using chi-square tests, this relationship
was found to be highly significant (p < 0.001, chi2 = 19.51; p value = 0.00006). Notably, Cramer’s
V coefficient was very high (0.921), indicating that the effect size of PRP treatment duration on
healing is very large (84.8%). We could suggest that the use of al-PRP in the healing of CNHWs is a
promising approach. Further studies with larger sample sizes and long follow-ups are needed to
obtain multivariate models to explain which factors favour the healing of ulcers treated with PRP
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