Compartir
Título
Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Aging
Número de la revista
2
Datos de la obra
Mejías-Peña, Y., Estébanez, B., Rodriguez-Miguelez, P., Fernandez-Gonzalo, R., Almar, M., de Paz, J. A., González-Gallego, J., & Cuevas, M. J. (2017). Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects. Aging, 9(2), 408-418. https://doi.org/10.18632/AGING.101167
Editor
Board
Fecha
2017-02-02
Zusammenfassung
[EN]Aging is associated with a decline in autophagy and a state of low-grade inflammation which further affects apoptosis and autophagy. Importantly, these alterations could reverse with regular physical activity. This study assessed the effects of a resistance exercise training program on autophagy, NLRP3 inflammasome, and apoptosis in peripheral blood mononuclear cells (PBMCs) from old subjects. Twenty-six healthy women and men (age, 69.6±1.5 yr) were randomized to a training (TG) or a control (CG) group. TG performed an 8-week resistance training program, while CG followed their daily routines. Protein expression of beclin-1, Atg12, Atg16 and LAMP-2 increased following the training program, while expression of p62/SQSTM1 and phosphorylation of ULK-1 at Ser757 were significantly lower. Resistance exercise also induced a decrease in NLRP3 expression and in the caspase-1/procaspase-1 ratio. Expression of Bcl-2 and Bcl-xL, as well as the Bad/BcL-2 ratio were reduced, and there was a significant decrease in the protein content of caspase-3. The results obtained seem to indicate that 8-week resistance training stimulates autophagy, prevents NLRP3 inflammasome activation, and reduces apoptosis in PBMCs from elderly subjects. These data could have a significant impact in prevention and rehabilitation programs currently employed in elderly population.
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/MINECO/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia /DEP2013-47659-R/ES/ESTUDIO DE LA AUTOFAGIA EN RESPUESTA A PROGRAMAS DE ENTRENAMIENTO FISICO COMO BASE PARA NUEVAS ESTRATEGIAS TERAPEUTICAS DE ENVEJECIMIENTO SALUDABLE
- info:eu-repo/grantAgreement/ MECD/ Programa Estatal de Promoción del Talento y su Empleabilidad / FPU15/05051/ES/ESTUDIO DE LA AUTOFAGIA EN RESPUESTA A PROGRAMAS DE ENTRENAMIENTO FISICO COMO BASE PARA NUEVAS ESTRATEGIAS TERAPEUTICAS DE ENVEJECIMIENTO SALUDABLE
URI
DOI
Aparece en las colecciones
- Untitled [5086]
Dateien zu dieser Ressource
Tamaño:
655.1
xmlui.dri2xhtml.METS-1.0.size-kilobytes
Formato:
Adobe PDF