dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Mejías Peña, Yubisay Noiraly | |
dc.contributor.author | Estébanez González, Brisamar | |
dc.contributor.author | Rodríguez Miguélez, Paula | |
dc.contributor.author | Fernández Gonzalo, Rodrigo | |
dc.contributor.author | Almar Galiana, Maríamar | |
dc.contributor.author | Paz Fernández, José Antonio de | |
dc.contributor.author | González Gallego, Javier | |
dc.contributor.author | Cuevas González, María José | |
dc.contributor.other | Fisiologia | es_ES |
dc.date | 2017-02-02 | |
dc.date.accessioned | 2024-01-16T13:06:31Z | |
dc.date.available | 2024-01-16T13:06:31Z | |
dc.identifier.citation | Mejías-Peña, Y., Estébanez, B., Rodriguez-Miguelez, P., Fernandez-Gonzalo, R., Almar, M., de Paz, J. A., González-Gallego, J., & Cuevas, M. J. (2017). Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects. Aging, 9(2), 408-418. https://doi.org/10.18632/AGING.101167 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/17634 | |
dc.description.abstract | [EN]Aging is associated with a decline in autophagy and a state of low-grade inflammation which further affects apoptosis and autophagy. Importantly, these alterations could reverse with regular physical activity. This study assessed the effects of a resistance exercise training program on autophagy, NLRP3 inflammasome, and apoptosis in peripheral blood mononuclear cells (PBMCs) from old subjects. Twenty-six healthy women and men (age, 69.6±1.5 yr) were randomized to a training (TG) or a control (CG) group. TG performed an 8-week resistance training program, while CG followed their daily routines. Protein expression of beclin-1, Atg12, Atg16 and LAMP-2 increased following the training program, while expression of p62/SQSTM1 and phosphorylation of ULK-1 at Ser757 were significantly lower. Resistance exercise also induced a decrease in NLRP3 expression and in the caspase-1/procaspase-1 ratio. Expression of Bcl-2 and Bcl-xL, as well as the Bad/BcL-2 ratio were reduced, and there was a significant decrease in the protein content of caspase-3. The results obtained seem to indicate that 8-week resistance training stimulates autophagy, prevents NLRP3 inflammasome activation, and reduces apoptosis in PBMCs from elderly subjects. These data could have a significant impact in prevention and rehabilitation programs currently employed in elderly population. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Board | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Unported | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | * |
dc.subject | Fisiología | es_ES |
dc.subject.other | elderly | es_ES |
dc.subject.other | autophagy | es_ES |
dc.subject.other | inflammasome | es_ES |
dc.subject.other | apoptosis | es_ES |
dc.subject.other | resistance exercise | es_ES |
dc.title | Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.18632/AGING.101167 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia /DEP2013-47659-R/ES/ESTUDIO DE LA AUTOFAGIA EN RESPUESTA A PROGRAMAS DE ENTRENAMIENTO FISICO COMO BASE PARA NUEVAS ESTRATEGIAS TERAPEUTICAS DE ENVEJECIMIENTO SALUDABLE | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ MECD/ Programa Estatal de Promoción del Talento y su Empleabilidad / FPU15/05051/ES/ESTUDIO DE LA AUTOFAGIA EN RESPUESTA A PROGRAMAS DE ENTRENAMIENTO FISICO COMO BASE PARA NUEVAS ESTRATEGIAS TERAPEUTICAS DE ENVEJECIMIENTO SALUDABLE | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1945-4589 | |
dc.journal.title | Aging | es_ES |
dc.volume.number | 9 | es_ES |
dc.issue.number | 2 | es_ES |
dc.page.initial | 408 | es_ES |
dc.page.final | 418 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 2410.10 Fisiología Humana | es_ES |