Compartir
Título
Mitochondrial function and mitophagy in the elderly: effects of exercise
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Oxidative Medicine and Cellular Longevity
Número de la revista
2012798
Datos de la obra
Moreira, O. C., Estébanez, B., Martínez-Florez, S., De Paz, J. A., Cuevas, M. J., & González-Gallego, J. (2017). Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise [Review of Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise]. Oxidative Medicine and Cellular Longevity, 2017. Hindawi Limited. https://doi.org/10.1155/2017/2012798
Editor
Hindawi
Fecha
2017
ISSN
1942-0900
Zusammenfassung
[EN] Aging is a natural, multifactorial and multiorganic phenomenon wherein there are gradual physiological and pathological changes over time. Aging has been associated with a decrease of autophagy capacity and mitochondrial functions, such as biogenesis, dynamics, and mitophagy. These processes are essential for the maintenance of mitochondrial structural integrity and, therefore, for cell life, since mitochondrial dysfunction leads to an impairment of energy metabolism and increased production of reactive oxygen species, which consequently trigger mechanisms of cellular senescence and apoptotic cell death. Moreover, reduced mitochondrial function can contribute to age-associated disease phenotypes in model organisms and humans. Literature data show beneficial effects of exercise on the impairment of mitochondrial biogenesis and dynamics and on the decrease in the mitophagic capacity associated to aging. Thus, exercise could have effects on the major cell signaling pathways that are involved in the mitochondria quality and quantity control in the elderly. Although it is known that several exercise protocols are able to modify the activity and turnover of mitochondria, further studies are necessary in order to better identify the mechanisms of interaction between mitochondrial functions, aging, and physical activity, as well as to analyze possible factors influencing these processes.
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/ MINECO / Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia / DEP2013-47659-R /ES / ESTUDIO DE LA AUTOFAGIA EN RESPUESTA A PROGRAMAS DE ENTRENAMIENTO FISICO COMO BASE PARA NUEVAS ESTRATEGIAS TERAPEUTICAS DE ENVEJECIMIENTO SALUDABLE
- info:eu-repo/grantAgreement/ MECD/ Programa Estatal de Promoción del Talento y su Empleabilidad / FPU15/05051 /ES/ESTUDIO DE LA AUTOFAGIA EN RESPUESTA A PROGRAMAS DE ENTRENAMIENTO FISICO COMO BASE PARA NUEVAS ESTRATEGIAS TERAPEUTICAS DE ENVEJECIMIENTO SALUDABLE
URI
DOI
Aparece en las colecciones
- Untitled [5086]
Dateien zu dieser Ressource
Tamaño:
1.975
xmlui.dri2xhtml.METS-1.0.size-megabytes
Formato:
Adobe PDF