Mostra i principali dati dell'item
dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Costa Moreira, Osvaldo | |
dc.contributor.author | Estébanez González, Brisamar | |
dc.contributor.author | Martínez Flórez, Susana | |
dc.contributor.author | Paz Fernández, José Antonio de | |
dc.contributor.author | Cuevas González, María José | |
dc.contributor.author | González Gallego, Javier | |
dc.contributor.other | Fisiologia | es_ES |
dc.date | 2017 | |
dc.date.accessioned | 2024-01-17T10:05:28Z | |
dc.date.available | 2024-01-17T10:05:28Z | |
dc.identifier.citation | Moreira, O. C., Estébanez, B., Martínez-Florez, S., De Paz, J. A., Cuevas, M. J., & González-Gallego, J. (2017). Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise [Review of Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise]. Oxidative Medicine and Cellular Longevity, 2017. Hindawi Limited. https://doi.org/10.1155/2017/2012798 | es_ES |
dc.identifier.issn | 1942-0900 | |
dc.identifier.uri | https://hdl.handle.net/10612/17644 | |
dc.description.abstract | [EN] Aging is a natural, multifactorial and multiorganic phenomenon wherein there are gradual physiological and pathological changes over time. Aging has been associated with a decrease of autophagy capacity and mitochondrial functions, such as biogenesis, dynamics, and mitophagy. These processes are essential for the maintenance of mitochondrial structural integrity and, therefore, for cell life, since mitochondrial dysfunction leads to an impairment of energy metabolism and increased production of reactive oxygen species, which consequently trigger mechanisms of cellular senescence and apoptotic cell death. Moreover, reduced mitochondrial function can contribute to age-associated disease phenotypes in model organisms and humans. Literature data show beneficial effects of exercise on the impairment of mitochondrial biogenesis and dynamics and on the decrease in the mitophagic capacity associated to aging. Thus, exercise could have effects on the major cell signaling pathways that are involved in the mitochondria quality and quantity control in the elderly. Although it is known that several exercise protocols are able to modify the activity and turnover of mitochondria, further studies are necessary in order to better identify the mechanisms of interaction between mitochondrial functions, aging, and physical activity, as well as to analyze possible factors influencing these processes. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Hindawi | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Fisiología | es_ES |
dc.subject.other | envejecimiento | es_ES |
dc.subject.other | función mitocondrial | es_ES |
dc.subject.other | mitofagia | es_ES |
dc.subject.other | ejercicio físico | es_ES |
dc.subject.other | tercera edad | es_ES |
dc.title | Mitochondrial function and mitophagy in the elderly: effects of exercise | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1155/2017/2012798 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ MINECO / Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia / DEP2013-47659-R /ES / ESTUDIO DE LA AUTOFAGIA EN RESPUESTA A PROGRAMAS DE ENTRENAMIENTO FISICO COMO BASE PARA NUEVAS ESTRATEGIAS TERAPEUTICAS DE ENVEJECIMIENTO SALUDABLE | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ MECD/ Programa Estatal de Promoción del Talento y su Empleabilidad / FPU15/05051 /ES/ESTUDIO DE LA AUTOFAGIA EN RESPUESTA A PROGRAMAS DE ENTRENAMIENTO FISICO COMO BASE PARA NUEVAS ESTRATEGIAS TERAPEUTICAS DE ENVEJECIMIENTO SALUDABLE | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1942-0994 | |
dc.journal.title | Oxidative Medicine and Cellular Longevity | es_ES |
dc.volume.number | 2017 | es_ES |
dc.issue.number | 2012798 | es_ES |
dc.page.initial | 1 | es_ES |
dc.page.final | 13 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 2410 Biología Humana | es_ES |
dc.subject.unesco | 2402.15 Envejecimiento Somático | es_ES |
Files in questo item
Questo item appare nelle seguenti collezioni
-
Untitled [5446]