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Título
Resistance training diminishes the expression of exosome CD63 protein without modification of plasma miR-146a-5p and cfDNA in the elderly
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Nutrients
Número de la revista
2
Datos de la obra
Estébanez, B., Visavadiya, N. P., de Paz, J. A., Whitehurst, M., Cuevas, M. J., González-Gallego, J., & Huang, C.-J. (2021). Resistance training diminishes the expression of exosome cd63 protein without modification of plasma mir-146a-5p and cfdna in the elderly. Nutrients, 13(2), 1-13. https://doi.org/10.3390/NU13020665
Editor
MDPI
Fecha
2021-02-19
Résumé
[EN] Aging-associated inflammation is characterized by senescent cell-mediated secretion of high levels of inflammatory mediators, such as microRNA (miR)-146a. Moreover, a rise of circulating cell-free DNA (cfDNA) is also related to systemic inflammation and frailty in the elderly. Exosome-mediated cell-to-cell communication is fundamental in cellular senescence and aging. The plasma changes in exercise-promoted miR-146a-5p, cfDNA, and exosome release could be the key to facilitate intercellular communication and systemic adaptations to exercise in aging. Thirty-eight elderly subjects (28 trained and 10 controls) volunteered in an 8-week resistance training protocol. The levels of plasma miR-146a-5p, cfDNA, and exosome markers (CD9, CD14, CD63, CD81, Flotillin [Flot]-1, and VDAC1) were measured prior to and following training. Results showed no changes in plasma miR-146a-5p and cfDNA levels with training. The levels of exosome markers (Flot-1, CD9, and CD81) as well as exosome-carried proteins (CD14 and VDAC1) remained unchanged, whereas an attenuated CD63 response was found in the trained group compared to the controls. These findings might partially support the anti-inflammatory effect of resistance training in the elderly as evidenced by the diminishment of exosome CD63 protein expression, without modification of plasma miR-146a-5p and cfDNA.
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