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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Estébanez González, Brisamar | |
dc.contributor.author | Visavadiya, Nishant P. | |
dc.contributor.author | Paz Fernández, José Antonio de | |
dc.contributor.author | Whitehurst, Michael | |
dc.contributor.author | Cuevas González, María José | |
dc.contributor.author | González Gallego, Javier | |
dc.contributor.author | Huang, Chun-Jung | |
dc.contributor.other | Fisiologia | es_ES |
dc.date | 2021-02-19 | |
dc.date.accessioned | 2024-01-18T12:29:17Z | |
dc.date.available | 2024-01-18T12:29:17Z | |
dc.identifier.citation | Estébanez, B., Visavadiya, N. P., de Paz, J. A., Whitehurst, M., Cuevas, M. J., González-Gallego, J., & Huang, C.-J. (2021). Resistance training diminishes the expression of exosome cd63 protein without modification of plasma mir-146a-5p and cfdna in the elderly. Nutrients, 13(2), 1-13. https://doi.org/10.3390/NU13020665 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/17670 | |
dc.description.abstract | [EN] Aging-associated inflammation is characterized by senescent cell-mediated secretion of high levels of inflammatory mediators, such as microRNA (miR)-146a. Moreover, a rise of circulating cell-free DNA (cfDNA) is also related to systemic inflammation and frailty in the elderly. Exosome-mediated cell-to-cell communication is fundamental in cellular senescence and aging. The plasma changes in exercise-promoted miR-146a-5p, cfDNA, and exosome release could be the key to facilitate intercellular communication and systemic adaptations to exercise in aging. Thirty-eight elderly subjects (28 trained and 10 controls) volunteered in an 8-week resistance training protocol. The levels of plasma miR-146a-5p, cfDNA, and exosome markers (CD9, CD14, CD63, CD81, Flotillin [Flot]-1, and VDAC1) were measured prior to and following training. Results showed no changes in plasma miR-146a-5p and cfDNA levels with training. The levels of exosome markers (Flot-1, CD9, and CD81) as well as exosome-carried proteins (CD14 and VDAC1) remained unchanged, whereas an attenuated CD63 response was found in the trained group compared to the controls. These findings might partially support the anti-inflammatory effect of resistance training in the elderly as evidenced by the diminishment of exosome CD63 protein expression, without modification of plasma miR-146a-5p and cfDNA. | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Fisiología | es_ES |
dc.subject.other | Aging | es_ES |
dc.subject.other | Cell-free DNA | es_ES |
dc.subject.other | Exercise-promoted exosomes | es_ES |
dc.subject.other | Extracellular vesicles | es_ES |
dc.subject.other | Inflammaging | es_ES |
dc.subject.other | MicroRNAs | es_ES |
dc.subject.other | Physical activity | es_ES |
dc.subject.other | Strength training | es_ES |
dc.title | Resistance training diminishes the expression of exosome CD63 protein without modification of plasma miR-146a-5p and cfDNA in the elderly | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3390/nu13020665 | |
dc.description.peerreviewed | SI | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2072-6643 | |
dc.journal.title | Nutrients | es_ES |
dc.volume.number | 13 | es_ES |
dc.issue.number | 2 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3201.07 Geriatría | es_ES |
dc.subject.unesco | 3201 Ciencias Clínicas | es_ES |
dc.description.project | Funding for this project was provided by the Department of Exercise Science and Health Promotion at Florida Atlantic University and supported by grants from the EXERNET Research Network on Physical Exercise and Health (09/UPB/19 and 45/UPB/20) and the IN MOTU SALUS Research Network on Molecular and Cellular Basis of Physical Exercise for Health and Performance (14/UPB/19 and 09/UPB/20). B. Estébanez was supported by a fellowship from the Ministry of Science, Innovation and Universities, Government of Spain (FPU fellowship, reference FPU15/05051; EST18/00256 | es_ES |
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