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Título
Improvement of albendazole bioavailability with menbutone administration in sheep
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Animals
Número de la revista
4
Cita Bibliográfica
.Diez, R., Diez, M. J., Garcia, J. J., Rodríguez, J. M., Lopez, C., Fernandez, N., Sierra, M., & Sahagun, A. M. (2022). Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep. Animals, 12(4). https://doi.org/10.3390/ANI12040463
Editorial
MDPI
Fecha
2022
Resumen
[EN] The pharmacokinetic interaction between a benzimidazole (albendazole, ABZ) and a choleretic drug (menbutone, MEN) was evaluated in sheep. The plasma disposition of albendazole sulfoxide (ABZSO, active metabolite) and albendazole sulfone (ABZSO2, inactive metabolite) was investigated following an oral administration of albendazole (ABZ) (5 mg/kg) alone or with menbutone (MEN) (intramuscular, 10 mg/kg). Blood samples were collected over 3 days post-treatment, and drug plasma concentrations were measured by high performance liquid chromatography (HPLC). ABZSO was measured from 0.5 to 48 h, and ABZSO2 from 2 to 60 h. No parent drug was detected at any sampling time. Mean maximum plasma concentration (Cmax) and the area under the plasma concentration-time curve (AUC) were 12.8% and 21.5% higher for ABZSO when ABZ and MENwere administered together, which indicates a significant increase in the amount absorbed. The rate of absorption was not modified, with similar values for the time to reach Cmax (tmax) (11.5 h with ABZ + MEN and 10.7 h with ABZ treatment), although no significant differences were observed for these latter pharmacokinetic parameters. Regarding ABZSO2, Cmax, AUC and tmax values were similar after both treatments (ABZ or ABZ + MEN). The results obtained indicate that co-administration of ABZ and MEN may be an interesting and practical option to increase the efficacy of this anthelmintic.
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