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Título
A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non‐Alcoholic Fatty Liver Disease
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Molecular Nutrition & Food Research
Número de la revista
20
Datos de la obra
Petrov, P. D., García-Mediavilla, M. V., Guzmán, C., Porras, D., Nistal González, E., Martínez-Flórez, S., Castell, J. V., González-Gallego, J., Sánchez-Campos, S., & Jover, R. (2019). A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non-Alcoholic Fatty Liver Disease. Molecular Nutrition and Food Research, 63(20). https://doi.org/10.1002/MNFR.201900487
Editor
Wiley
Fecha
2019
ISSN
1613-4125
Résumé
[EN] Scope: Gut microbiota contributes to non-alcoholic fatty liver disease (NAFLD) pathogenesis by multiple mechanisms not yet completely understood. Novel differential features between germ-free mice (GFm) transplanted with protective or non-protective cecal microbiota against NAFLD are investigated. Methods and results: Gut microbiota composition, plasma, and fecal bile acids (BAs) and liver mRNAs are quantified in GFm recipients from four donor mice differing in NAFLD severity (control diet, high-fat diet [HFD]-responder, HFD-non-responder, and quercetin-supplemented HFD). Transplanted GFm are on control or HFD for 16-weeks. Multivariate analysis shows that GFm colonized with microbiota from HFD-non-responder and quercetin supplemented-HFD donors (protected against NAFLD) clusters together, whereas GFm colonized with microbiota from control and HFD-responder mice (non-protected against NAFLD) establishes another cluster. Protected phenotype is associated with increased gut Desulfovibrio and Oscillospira, reduced gut Bacteroides and Oribacterium, lower primary and higher secondary BAs in plasma and feces, induction of hepatic BA transporters, and repression of hepatic lipogenic and BA synthesis genes. Conclusion: Protective gut microbiota associates with increased specific secondary BAs, which likely inhibit lipogenic pathways and enhance bile flow in the liver. This novel cross-talk between gut and liver, via plasma BAs, that promotes protection against NAFLD may have clinical and nutritional relevance
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ID proyecto
- info:eu-repo/grantAgreement/ ISCIII / Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia / PI17/01089 /ES/ NUEVOS MECANISMOS Y BIOMARCADORES DIAGNOSTICOS EN LA COLESTASIS IATROGENICA //
- info:eu-repo/grantAgreement/ MINECO/ Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia / BFU2013-48141-R/ES/ ESTUDIO DEL EFECTO DEL TRATAMIENTO CON QUERCETINA Y DEL TRASPLANTE DE MICROBIOTA INTESTINAL EN MODELOS EXPERIMENTALES DE HIGADO GRASO NO ALCOHOLICO //
- info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/BFU2017-87960-R/ES/EFECTO DEL EJERCICIO FISICO Y QUERCETINA Y DEL TRASPLANTE DE MICROBIOTA INTESTINAL PROTECTORA O PREDISPONENTE ADICIONADA CON AKKERMANSIA MUCINIPHILA EN MODELOS DE NAFLD//
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