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Título
Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High‐Fat Diet Determine Non‐Alcoholic Fatty Liver Disease Development in Germ‐Free Mice
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Molecular Nutrition & Food Research
Número de la revista
8
Cita Bibliográfica
Porras, D., Nistal González, E., Martínez-Flórez, S., Olcoz, J. L., Jover, R., Jorquera, F., González-Gallego, J., García-Mediavilla, M. V., & Sánchez-Campos, S. (2019). Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High-Fat Diet Determine Non-Alcoholic Fatty Liver Disease Development in Germ-Free Mice. Molecular Nutrition and Food Research, 63(8). https://doi.org/10.1002/MNFR.201800930
Editorial
Wiley
Fecha
2019
ISSN
1613-4125
Resumen
[EN] Scope: Modulation of intestinal microbiota has emerged as a new therapeutic approach for non-alcoholic fatty liver disease (NAFLD). Herein, it is addressed whether gut microbiota modulation by quercetin and intestinal microbiota transplantation can influence NAFLD development. Methods and results: Gut microbiota donor mice are selected according to their response to high-fat diet (HFD) and quercetin in terms of obesity and NAFLD-related biomarkers. Germ-free recipients displayed metabolic phenotypic differences derived from interactions between microbiota transplanted, diets, and quercetin. Based on the evaluation of hallmark characteristics of NAFLD, it is found that gut microbiota transplantation from the HFD-non-responder donor and the HFD-fed donor with the highest response to quercetin results in a protective phenotype against HFD-induced NAFLD, in a mechanism that involves gut–liver axis alteration blockage in these receivers. Gut microbiota from the HFD-responder donor predisposed transplanted germ-free mice to NAFLD. Divergent protective and deleterious metabolic phenotypes exhibited are related to definite microbial profiles in recipients, highlighting the predominant role of Akkermansia genus in the protection from obesity-associated NAFLD development. Conclusions: The results provide scientific support for the prebiotic capacity of quercetin and the transfer of established metabolic profiles through gut microbiota transplantation as a protective strategy against the development of obesity-related NAFLD
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Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/MINECO/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/BFU2013-48141-R/ES/ ESTUDIO DEL EFECTO DEL TRATAMIENTO CON QUERCETINA Y DEL TRASPLANTE DE MICROBIOTA INTESTINAL EN MODELOS EXPERIMENTALES DE HIGADO GRASO NO ALCOHOLICO//
- info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/BFU2017-87960-R/ES/EFECTO DEL EJERCICIO FISICO Y QUERCETINA Y DEL TRASPLANTE DE MICROBIOTA INTESTINAL PROTECTORA O PREDISPONENTE ADICIONADA CON AKKERMANSIA MUCINIPHILA EN MODELOS DE NAFLD//
- info:eu-repo/grantAgreement/Junta de Castilla y León LE135U13/ES/EFECTO DE FLAVONOIDES SOBRE EL DESARROLLO DE ESTEATOSIS, ESTEATOHEPATITIS Y HEPATOCARCINOMA EN MODELOS IN VIVO E IN VITRO DE NAFLD//
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