Compartir
Título
Identification of Candidate Genes for Reactivity in Guzerat (Bos indicus) Cattle: A Genome-Wide Association Study
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
PLOS ONE
Número de la revista
1
Datos de la obra
Dos Santos, F. C., Peixoto, M. G. C. D., Fonseca, P. A. D. S., Pires, M. D. F. Á., Ventura, R. V., Rosse, I. D. C., ... & Carvalho, M. R. S. (2017). Identification of candidate genes for reactivity in guzerat (Bos indicus) cattle: a genome-wide association study. PLoS One, 12(1), e0169163.
Editor
Plos
Fecha
2017
Résumé
[EN] Temperament is fundamental to animal production due to its direct influence on the animalherdsman relationship. When compared to calm animals, the aggressive, anxious or fearful ones exhibit less weight gain, lower reproductive efficiency, decreased milk production and higher herd maintenance costs, all of which contribute to reduced profits. However, temperament is a trait that is complex and difficult to assess. Recently, a new quantitative system, REATEST®, for assessing reactivity, a phenotype of temperament, was developed. Herein, we describe the results of a Genome-wide association study for reactivity, assessed using REATEST® with a sample of 754 females from five dual-purpose (milk and meat production) Guzerat (Bos indicus) herds. Genotyping was performed using a 50k SNP chip and a twostep mixed model approach (Grammar-Gamma) with a one-by-one marker regression was used to identify QTLs. QTLs for reactivity were identified on chromosomes BTA1, BTA5, BTA14, and BTA25. Five intronic and two intergenic markers were significantly associated with reactivity. POU1F1, DRD3, VWA3A, ZBTB20, EPHA6, SNRPF and NTN4 were identified as candidate genes. Previous QTL reports for temperament traits, covering areas surrounding the SNPs/genes identified here, further corroborate these associations. The seven genes identified in the present study explain 20.5% of reactivity variance and give a better understanding of temperament biology. Introduction
Materia
Palabras clave
Peer review
SI
URI
DOI
Versión del editor
Aparece en las colecciones
- Untitled [5086]
Fichier(s) constituant ce document
Tamaño:
1.464
xmlui.dri2xhtml.METS-1.0.size-megabytes
Formato:
Adobe PDF