dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Dos Santos, Fernanda Caroline | |
dc.contributor.author | Diniz Peixoto, Maria Gabriela Campolina | |
dc.contributor.author | De Souza Fonseca, Pablo Augusto | |
dc.contributor.author | Ávila Pires, Maria de Fátima | |
dc.contributor.author | Vieira Ventura, Ricardo | |
dc.contributor.author | Da Cruz Rosse, Izinara | |
dc.contributor.author | Tomita Bruneli, Frank Angelo | |
dc.contributor.author | Machado, Marco Antonio | |
dc.contributor.author | Santos Carvalho, Maria Raquel | |
dc.contributor.other | Producción Animal | es_ES |
dc.date | 2017 | |
dc.date.accessioned | 2024-01-30T13:10:29Z | |
dc.date.available | 2024-01-30T13:10:29Z | |
dc.identifier.citation | Dos Santos, F. C., Peixoto, M. G. C. D., Fonseca, P. A. D. S., Pires, M. D. F. Á., Ventura, R. V., Rosse, I. D. C., ... & Carvalho, M. R. S. (2017). Identification of candidate genes for reactivity in guzerat (Bos indicus) cattle: a genome-wide association study. PLoS One, 12(1), e0169163. | es_ES |
dc.identifier.other | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169163 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/17928 | |
dc.description.abstract | [EN] Temperament is fundamental to animal production due to its direct influence on the animalherdsman relationship. When compared to calm animals, the aggressive, anxious or fearful ones exhibit less weight gain, lower reproductive efficiency, decreased milk production and higher herd maintenance costs, all of which contribute to reduced profits. However, temperament is a trait that is complex and difficult to assess. Recently, a new quantitative system, REATEST®, for assessing reactivity, a phenotype of temperament, was developed. Herein, we describe the results of a Genome-wide association study for reactivity, assessed using REATEST® with a sample of 754 females from five dual-purpose (milk and meat production) Guzerat (Bos indicus) herds. Genotyping was performed using a 50k SNP chip and a twostep mixed model approach (Grammar-Gamma) with a one-by-one marker regression was used to identify QTLs. QTLs for reactivity were identified on chromosomes BTA1, BTA5, BTA14, and BTA25. Five intronic and two intergenic markers were significantly associated with reactivity. POU1F1, DRD3, VWA3A, ZBTB20, EPHA6, SNRPF and NTN4 were identified as candidate genes. Previous QTL reports for temperament traits, covering areas surrounding the SNPs/genes identified here, further corroborate these associations. The seven genes identified in the present study explain 20.5% of reactivity variance and give a better understanding of temperament biology. Introduction | es_ES |
dc.language | eng | es_ES |
dc.publisher | Plos | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Genética | es_ES |
dc.subject.other | GWAS | es_ES |
dc.subject.other | Temperament | es_ES |
dc.subject.other | Cattle | es_ES |
dc.title | Identification of Candidate Genes for Reactivity in Guzerat (Bos indicus) Cattle: A Genome-Wide Association Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0169163 | |
dc.description.peerreviewed | SI | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1932-6203 | |
dc.journal.title | PLOS ONE | es_ES |
dc.volume.number | 12 | es_ES |
dc.issue.number | 1 | es_ES |
dc.page.initial | e0169163 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3109 Ciencias Veterinarias | es_ES |
dc.subject.unesco | 3109.02 Genética | es_ES |
dc.description.project | We thank the farmers, who allowed the development of this project in their facilities. We thank to Mr. Peter Laspina for performing language review and for the valuable comments. This study was supported by Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Empresa Brasileira de Pesquisa Agropecuária (Embrapa). Maria Gabriela Campolina Diniz Peixoto was supported by the Fapemig—CVZ APQ 01353 e CVZ APQ 3182–5.04/07. MRSC has a fellowship from the CNPq– 307975/2010-0 and was supported by CNPq– 312068/2015-8 and 481018/2008-5 projects. MGCDP, RVV, MAM have fellowships from FAPEMIG. PASF has CNPq fellowship, FCS and ICR have CAPES fellowships. | es_ES |