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Título
The effects of endocrine disruptors on the male germline: an intergenerational health risk
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Biological Reviews
Número de la revista
4
Datos de la obra
Lombó, M., & Herráez, P. (2021). The effects of endocrine disruptors on the male germline: an intergenerational health risk. Biological Reviews, 96(4), 1243-1262. https://doi.org/10.1111/BRV.12701
Editor
Wiley
Fecha
2021
ISSN
1464-7931
Abstract
[EN] Environmental pollution is becoming one of the major concerns of society. Among the emerging contaminants, endocrine-disrupting chemicals (EDCs), a large group of toxicants, have been the subject of many scientific studies. Besides the capacity of these compounds to interfere with the endocrine system, they have also been reported to exert both genotoxic and epigenotoxic effects. Given that spermatogenesis is a coordinated process that requires the involvement of several steroid hormones and that entails deep changes in the chromatin, such as DNA compaction and epigenetic remodelling, it could be affected by male exposure to EDCs. A great deal of evidence highlights that these compounds have detrimental effects on male reproductive health, including alterations to sperm motility, sexual function, and gonad development. This review focuses on the consequences of paternal exposure to such chemicals for future generations, which still remain poorly known. Historically, spermatozoa have long been considered as mere vectors delivering the paternal haploid genome to the oocyte. Only recently have they been understood to harbour genetic and epigenetic information that plays a remarkable role during offspring early development and long-term health. This review examines the different modes of action by which the spermatozoa represent a key target for EDCs, and analyses the consequences of environmentally induced changes in sperm genetic and epigenetic information for subsequent generations
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Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/AGL2014-53167-C3-3-R/ES/Efecto de contaminantes emergentes en células de la línea germinal masculina: contribución paterna al desarrollo y herencia transgeneracional
- info:eu-repo/grantAgreement/MINECO/Programa Estatal de Promoción del Talento y su Empleabilidad/BES- 2015-071885/ES
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