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dc.contributor | Facultad de Ciencias Economicas y Empresariales | es_ES |
dc.contributor.author | López Flores, Mariana Alejandra | |
dc.contributor.author | Honrado Franco, Emiliano | |
dc.contributor.author | Sánchez Cousido, Luis Felipe | |
dc.contributor.author | Minguito Carazo, Carlos | |
dc.contributor.author | Sanz Guadarrama, Oscar | |
dc.contributor.author | López González, Laura | |
dc.contributor.author | Vallejo Pascual, María Eva | |
dc.contributor.author | Molina de la Torre, Antonio José | |
dc.contributor.author | García Palomo, Andrés | |
dc.contributor.author | López González, Ana | |
dc.contributor.other | Métodos Cuantitativos para la Economía y la Empresa | es_ES |
dc.date | 2022 | |
dc.date.accessioned | 2024-02-22T11:11:40Z | |
dc.date.available | 2024-02-22T11:11:40Z | |
dc.identifier.citation | López Flores, M., Honrado Franco, E., Sánchez Cousido, L. F., Minguito-Carazo, C., Sanz Guadarrama, O., López González, L., Vallejo Pascual, M. E., Molina de la Torre, A. J., García Palomo, A., y López González, A. (2022). Relationship between Aldehyde Dehydrogenase, PD-L1 and Tumor-Infiltrating Lymphocytes with Pathologic Response and Survival in Breast Cancer. Cancers, 14(18). https://doi.org/10.3390/CANCERS14184418 | es_ES |
dc.identifier.other | https://www.mdpi.com/2072-6694/14/18/4418 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/18413 | |
dc.description.abstract | [EN] Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell (CSC) marker related to clinical outcomes in breast cancer (BC). The aim of this study was to analyze the relationship between ALDH1A1, programmed death ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in triple negative (TN) and human epidermal growth factor receptor 2-positive (HER2+) BC tumors, and its association with clinicopathological characteristics and outcomes. A retrospective, historical cohort study of patients diagnosed with early or locally advanced BC treated with neoadjuvant chemotherapy was conducted. ALDH1A1, PD-L1 expression and TILs were assessed using immunohistochemistry. A total of 75 patients were analyzed (42.7% TN, 57.3% HER2+ tumors). ALDH1A1+ was related to HTILs (p = 0.005) and PD-L1+ tumors (p = 0.004). ALDH1A1+ tumors presented higher CD3+ (p = 0.008), CD4+ (p = 0.005), CD8+ (p = 0.003) and CD20+ (p = 0.006) TILs. ALDH1A1+ (p = 0.018), PD-L1+ (p = 0.004) and HTILs (p < 0.001) were related to smaller tumors. ALDH1A1+ was related to pathologic complete response (pCR) (p = 0.048). At the end of the follow-up (54.4 [38.3–87.6] months), 47 patients (62.7%) remained disease-free, and 20 (26.7%) had died. HTILs were related to improved disease-free survival (p = 0.027). ALDH1A1+ was related to PD-L1+ and HITLs, that might be related to higher pCR rates with neoadjuvant therapy. | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Estadística | es_ES |
dc.subject | Medicina. Salud | es_ES |
dc.subject.other | Aldehyde dehydrogenase; | es_ES |
dc.subject.other | Breast cancer stem cells | es_ES |
dc.subject.other | Breast cancer | es_ES |
dc.title | Relationship between Aldehyde Dehydrogenase, PD-L1 and Tumor-Infiltrating Lymphocytes with Pathologic Response and Survival in Breast Cancer | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3390/cancers14184418 | |
dc.description.peerreviewed | SI | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2072-6694 | |
dc.journal.title | Cancers | es_ES |
dc.volume.number | 14 | es_ES |
dc.issue.number | 18 | es_ES |
dc.page.initial | 4418 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
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