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Título
Understanding microRNAs in the Context of Infection to Find New Treatments against Human Bacterial Pathogens
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Antibiotics
Número de la revista
3
Cita Bibliográfica
Mourenza, Á., Lorente-Torres, B., Durante, E., Llano-Verdeja, J., Aparicio, J. F., Fernández-López, A., Gil, J. A., Mateos, L. M., and Letek, M. (2022). Understanding microRNAs in the context of infection to find new treatments against human bacterial pathogens. Antibiotics (Basel), 11(3), Article e356. https://doi.org/10.3390/antibiotics11030356
Editorial
MDPI
Fecha
2022
Resumen
[EN] The development of RNA-based anti-infectives has gained interest with the successful
application of mRNA-based vaccines. Small RNAs are molecules of RNA of <200 nucleotides in
length that may control the expression of specific genes. Small RNAs include small interference RNAs
(siRNAs), Piwi-interacting RNAs (piRNAs), or microRNAs (miRNAs). Notably, the role of miRNAs
on the post-transcriptional regulation of gene expression has been studied in detail in the context of
cancer and many other genetic diseases. However, it is also becoming apparent that some human
miRNAs possess important antimicrobial roles by silencing host genes essential for the progress
of bacterial or viral infections. Therefore, their potential use as novel antimicrobial therapies has
gained interest during the last decade. The challenges of the transport and delivery of miRNAs
to target cells are important, but recent research with exosomes is overcoming the limitations in
RNA-cellular uptake, avoiding their degradation. Therefore, in this review, we have summarised the
latest developments in the exosomal delivery of miRNA-based therapies, which may soon be another
complementary treatment to pathogen-targeted antibiotics that could help solve the problem caused
by multidrug-resistant bacteria
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/JCYL/Programa de apoyo a proyectos de investigación/LE044P20/ES/Identificación de nuevas terapias combinatorias frente a patógenos intracelulares multirresistentes
URI
DOI
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