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Título
The Influence of Nutrition in Alzheimer's Disease: Neuroinflammation and the Microbiome vs. Transmissible Prion
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Frontiers in Neuroscience
Número de la revista
677777
Cita Bibliográfica
Sánchez Valdeón, L.; Casado Verdejo, I.; Seco Calvo, J. Á.; Fernández Fernández , J. A.; Fernández Martínez, M. N.; Bello-Corral, L. (2021). The Influence of Nutrition in Alzheimer's Disease: Neuroinflammation and the Microbiome vs. Transmissible Prion. Frontiers in Neuroscience, 15
Editorial
Sebastian Cerdan, Autonomous University of Madrid, Spain
Fecha
2021
Resumen
[EN] Alzheimer’s disease (AD) is a primary, progressive, neurodegenerative disorder. Many risk
factors for the development of AD have been investigated, including nutrition. Although it
has been proven that nutrition plays a role in AD, the precise mechanisms through which
nutrition exerts its influence remain undefined. The object of this study is to address
this issue by elucidating some of the mechanisms through which nutrition interacts with
AD. This work is a qualitative systematic bibliographic review of the current literature
searchable on various available databases, including PubMed, Web of Science, and
Google Scholar. Our evidence comprises 31 articles selected after a systematic search
process. Patients suffering with AD present a characteristic microbiome that promotes
changes in microglia generating a proinflammatory state. Many similarities exist between
AD and prion diseases, both in terms of symptoms and in the molecular mechanisms of
pathogenesis. Changes in the composition of the gut microbiome due to dietary habits
could be one of the environmental factors affecting the development of AD; however,
this is probably not the only factor. Similarly, the mechanism for self-propagation of
beta-amyloid seen in AD is similar to that seen in prions.
Materia
Palabras clave
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