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Título
Novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by Haemonchus contortus
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Facultad/Centro
Área de conocimiento
Título de la revista
Scientific Reports
Número de la revista
1
Datos de la obra
Valderas-García, E., Escala, N., Álvarez-Bardón, M., Castilla-Gómez de Agüero, V., Cambra-Pellejà, M., González del Palacio, L., Vallejo García, R., de la Vega, J., San Feliciano, A., del Olmo, E., Martínez-Valladares, M., & Balaña-Fouce, R. (2022). Novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by Haemonchus contortus. Scientific Reports, 12(1). https://doi.org/10.1038/S41598-022-17112-3
Editor
Nature Research
Fecha
2022
Zusammenfassung
[EN] The control of gastrointestinal nematodes in livestock is becoming increasingly difficult due to the limited number of available drugs and the rapid development of anthelmintic resistance. Therefore, it is imperative to develop new anthelmintics that are effective against nematodes. Under this context, we tested the potential toxicity of three compounds in mice and their potential anthelmintic efficacy in Mongolian gerbils infected with Haemonchus contortus. The compounds were selected from previous in vitro experiments: two diamine (AAD-1 and AAD-2) and one benzimidazole (2aBZ) derivatives. 2aBZ was also selected to test its efficacy in sheep. In Mongolian gerbils, the benzimidazole reduced the percentage of pre-adults present in the stomach of gerbils by 95% at a dose of 200 mg/kg. In sheep, there was a 99% reduction in the number of eggs shed in faeces after 7 days at a dose of 120 mg/kg and a 95% reduction in the number of worm adults present in the abomasum. In conclusion, 2aBZ could be considered a promising candidate for the treatment of helminth infections in small ruminants
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SI
ID proyecto
- info:eu-repo/grantAgreement/MINECO/Programa Estatal de Promoción del Talento y su Empleabilidad /RYC-2015-18368 /ES/ RYC-2015-18368//
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