Compartir
Título
Peripheral IFN-ɣ Production after Blood Stimulation with Different Mycobacterial Antigens in Goats Vaccinated against Paratuberculosis
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Vaccines
Número de la revista
10
Cita Bibliográfica
Fernández, M., Royo, M., Arteche-Villasol, N., Ferreras, M. C., Benavides, J., & Pérez, V. (2022). Peripheral IFN-ɣ Production after Blood Stimulation with Different Mycobacterial Antigens in Goats Vaccinated against Paratuberculosis. Vaccines, 10(10). https://doi.org/10.3390/VACCINES10101709
Editorial
MDPI
Fecha
2022
Resumen
[EN] Vaccination can be an efficient method for the control of paratuberculosis in ruminants. However, the official tuberculosis control tests cross-interfere with the animals vaccinated against paratuberculosis. In order to test and compare new antigens that could solve this problem, the production of interferon-gamma (IFN-γ) in peripheral blood at different post-vaccination days in experimental kids and adult goats, in field conditions, using the avian and bovine purified protein derivative (PPD), the johnin, two peptide cocktails of Mycobacterium bovis (PC-EC and PC-HP) and the antigens VK 055 and VK 067 of Mycobacterium avium subspecies paratuberculosis (Map) has been analyzed in vitro. The non-specific production of IFN-γ was observed after blood stimulation with the PC-EC and PC-HP cocktail in any sample from vaccinated animals, whereas it was detected when bovine PPD was used. These results support the possible use of these new Mycobacterium bovis antigens in the in the differentiation of animals vaccinated against paratuberculosis or infected with tuberculosis by improving the specificity of bovine PPD. In contrast, the two Map antigens tested in this study did not improve the sensitivity of johnin or avian PPD in the detection of vaccinated or Map-infected goats
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/MINECO/ Programa Nacional de Investigación Fundamental / AGL2012-39818-C02-01 /ES/ DESARROLLO DE MODELOS DE PATOGENIA E INMUNIZACION EN PARATUBERCULOSIS//
URI
DOI
Versión del editor
Aparece en las colecciones
- Artículos [5086]
Ficheros en el ítem
Tamaño:
1.212
xmlui.dri2xhtml.METS-1.0.size-megabytes
Formato:
Adobe PDF