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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Grau Pujol, Berta | |
dc.contributor.author | Martí Soler, Helena | |
dc.contributor.author | Escola, Valdemiro | |
dc.contributor.author | Demontis, Maria | |
dc.contributor.author | Jamine, Jose Carlos | |
dc.contributor.author | Gandasegui, Javier | |
dc.contributor.author | Muchisse, Osvaldo | |
dc.contributor.author | Cambra Pellejà, Maria | |
dc.contributor.author | Cossa, Anelsio | |
dc.contributor.author | Martínez Valladares, María | |
dc.contributor.author | Sacoor, Charfudin | |
dc.contributor.author | Van Lieshout, Lisette | |
dc.contributor.author | Cano, Jorge | |
dc.contributor.author | Giorgi, Emanuele | |
dc.contributor.author | Muñoz, Jose | |
dc.contributor.other | Sanidad Animal | es_ES |
dc.date | 2021 | |
dc.date.accessioned | 2024-03-15T07:52:04Z | |
dc.date.available | 2024-03-15T07:52:04Z | |
dc.identifier.citation | Grau-Pujol, B., Martí-Soler, H., Escola, V., Demontis, M., Jamine, J. C., Gandasegui, J., Muchisse, O., Cambra-Pellejà, M., Cossa, A., Martinez-Valladares, M., Sacoor, C., Lieshout, L. V., Cano, J., Giorgi, E., & Muñoz, J. (2021). Towards soil-transmitted helminths transmission interruption: The impact of diagnostic tools on infection prediction in a low intensity setting in Southern Mozambique. PLoS Neglected Tropical Diseases, 15(10). https://doi.org/10.1371/JOURNAL.PNTD.0009803 | es_ES |
dc.identifier.other | https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0009803 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/18965 | |
dc.description | Copyright: © 2021 Grau-Pujol et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | es_ES |
dc.description.abstract | [EN] World Health Organization goals against soil-transmitted helminthiases (STH) are pointing towards seeking their elimination as a public health problem: reducing to less than 2% the proportion of moderate and heavy infections. Some regions are reaching WHO goals, but transmission could rebound if strategies are discontinued without an epidemiological evalu-ation. For that, sensitive diagnostic methods to detect low intensity infections and localiza-tion of ongoing transmission are crucial. In this work, we estimated and compared the STH infection as obtained by different diagnostic methods in a low intensity setting. We conducted a cross-sectional study enrolling 792 participants from a district in Mozambique. Two stool samples from two consecutive days were collected from each participant. Samples were analysed by Telemann, Kato-Katz and qPCR for STH detection. We evaluated diagnostic sensitivity using a composite reference standard. By geostatistical methods, we estimated neighbourhood prevalence of at least one STH infection for each diagnostic method. We used environmental, demographical and socioeconomical indicators to account for any existing spatial heterogeneity in infection. qPCR was the most sensitive technique compared to composite reference standard: 92% (CI: 83%– 97%) for A. lumbricoides, 95% (CI: 88%– 98%) for T. trichiura and 95% (CI: 91%– 97%) for hookworm. qPCR also estimated the highest neighbourhood prevalences for at least one STH infection in a low intensity set-ting. While 10% of the neighbourhoods showed a prevalence above 20% when estimating with single Kato-Katz from one stool and Telemann from one stool, 86% of the neighbour-hoods had a prevalence above 20% when estimating with qPCR. In low intensity settings, STH estimated prevalence of infection may be underestimated if based on Kato-Katz. qPCR diagnosis outperformed the microscopy methods. Thus, implementation of qPCR based predictive maps at STH control and elimination programmes would disclose hidden transmission and facilitate targeted interventions for transmission interruption. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Medicina. Salud | es_ES |
dc.subject.other | Mozambique | es_ES |
dc.subject.other | Helminths | es_ES |
dc.subject.other | STH | es_ES |
dc.title | Towards soil-transmitted helminths transmission interruption: The impact of diagnostic tools on infection prediction in a low intensity setting in Southern Mozambique | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1371/JOURNAL.PNTD.0009803 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/ Programa Estatal de Promoción del Talento y su Empleabilidad / RYC-2015-18368 /ES/ // | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1935-2735 | |
dc.journal.title | PLOS Neglected Tropical Diseases | es_ES |
dc.volume.number | 15 | es_ES |
dc.issue.number | 10 | es_ES |
dc.page.initial | e0009803 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 5312.07 Sanidad | es_ES |
dc.subject.unesco | 32 Ciencias Médicas | es_ES |
dc.description.project | BGP and JM received financial support for this study from Mundo Sano Foundation (www. mundosano.org). JG was personally supported at the beginning of the work by the Ramo´n Areces Foundation and is now funded by the Spanish ‘Juan de la Cierva’ Programme, Ministry of Economy and Competitiveness (FJC-2018-38305). MMV is personally supported by the Spanish ‘Ramo´n y Cajal’ Programme, Ministry of Economy and Competitiveness (RYC-2015-18368). MCP is personally supported by Junta de Castilla y Leo´n and Fondo Social Europeo (LE-135-19). ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. CISM is supported by the Government of Mozambique and the Spanish Agency for International Development (AECID). Prof. Dr. P.C. Flu Foundation also founded this project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
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