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Título
Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
PLOS Neglected Tropical Diseases
Número de la revista
2
Datos de la obra
Gandasegui, J., Martínez-Valladares, M., Grau-Pujol, B., Krolewiecki, A. J., Balaña-Fouce, R., Gelaye, W., van Lieshout, L., Kepha, S., Mandomando, I., & Muñoz, J. (2020). Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials. PLoS Neglected Tropical Diseases, 14(2). https://doi.org/10.1371/JOURNAL.PNTD.0007931
Editor
Public Library of Science
Fecha
2020
Abstract
[EN] More than 1 billion people have been reported to be infected with at least one soil-transmitted helminth (STH) worldwide, according to the last published report of the World Health Organization (WHO) [1]. WHO guidelines for STH control mainly encompass periodic administration of benzimidazoles (albendazole or mebendazole) to at-risk people of the endemic areas [1]. However, extended use of benzimidazoles could entail a great selection pressure for parasitic-resistant strains. In veterinary medicine, anthelmintic resistance in gastrointestinal nematodes has been developed in response to their excessive use, and it is currently considered a serious threat to livestock health and welfare [2, 3]. In humans, the estimated efficacy of albendazole and mebendazole against Trichuris trichiura has been observed to significantly decrease over time [4]. This observed decrement in drug efficacy could be due to the development of anthelmintic resistance (among other reasons such as drug quality and administration, the increasing of drug-efficacy studies, improvements in sensitivity of diagnostic tools after treatment,
etc) after years of mass drug-administration campaigns, which is one of the major
oncerns in STH control
Materia
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Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/MINECO/ Programa Estatal de Promoción del Talento y su Empleabilidad/ RYC-2015-18368/ES/RYC-2015-18368//
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