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Título
CD160 serves as a negative regulator of NKT cells in acute hepatic injury
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Nature Communications
Número de la revista
1
Cita Bibliográfica
Kim, T. J., Park, G., Kim, J., Lim, S. A., Kim, J., Im, K., Shin, M. H., Fu, Y. X., Del Rio, María Luisa, Rodríguez Barbosa, J.I., Yee, C., Suh, K. S., Kim, S. J., Ha, S. J., & Lee, K. M. (2019). CD160 serves as a negative regulator of NKT cells in acute hepatic injury. Nature Communications, 10(1). https://doi.org/10.1038/S41467-019-10320-Y
Editorial
Nature Research
Fecha
2019
Resumen
[EN] CD160 and BTLA both bind to herpes virus entry mediator. Although a negative regulatory function of BTLA in natural killer T (NKT) cell activation has been reported, whether CD160 is also involved is unclear. By analyzing CD160−/− mice and mixed bone marrow chimeras, we show that CD160 is not essential for NKT cell development. However, CD160−/− mice exhibit severe liver injury after in vivo challenge with α-galactosylceramide (α-GalCer). Moreover, CD160−/− mice are more susceptible to Concanavalin A challenge, and display elevated serum AST and ALT levels, hyperactivation of NKT cells, and enhanced IFN-γ, TNF, and IL-4 production. Lastly, inhibition of BTLA by anti-BTLA mAb aggravates α-GalCer-induced hepatic injury in CD160−/− mice, suggesting that both CD160 and BTLA serve as non-overlapping negative regulators of NKT cells. Our data thus implicate CD160 as a co-inhibitory receptor that delivers antigen-dependent signals in NKT cells to dampen cytokine production during early innate immune activation
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URI
DOI
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