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Título
Phenotypic Characterization of Encephalitis and Immune Response in the Brains of Lambs Experimentally Infected with Spanish Goat Encephalitis Virus
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Animals
Número de la revista
8
Datos de la obra
Martínez, I. Z., Pérez‐martínez, C., Salinas, L. M., Juste, R. A., García Marín, J. F., & Balseiro, A. (2020). Phenotypic characterization of encephalitis and immune response in the brains of lambs experimentally infected with Spanish goat encephalitis virus. Animals, 10(8), Article e1373. https://doi.org/10.3390/ANI10081373
Editor
MDPI
Fecha
2020
Zusammenfassung
[EN]Spanish goat encephalitis virus (SGEV), a novel subtype of tick-borne flavivirus closely
related to louping ill virus, causes a neurological disease in experimentally infected goats and lambs.
Here, the distribution of microglia, T and B lymphocytes, and astrocytes was determined in the
encephalon and spinal cord of eight Assaf lambs subcutaneously infected with SGEV. Cells were
identified based on immunohistochemical staining against Iba1 (microglia), CD3 (T lymphocytes),
CD20 (B lymphocytes), and glial fibrillary acidic protein (astrocytes). In glial foci and perivascular
cu ng areas, microglia were the most abundant cell type (45.4% of immunostained cells), followed
by T lymphocytes (18.6%) and B lymphocytes (4.4%). Thalamus, hypothalamus, corpus callosum,
and medulla oblongata contained the largest areas occupied by glial foci. Reactive astrogliosis
occurred to a greater extent in the lumbosacral spinal cord than in other regions of the central nervous
system. Lesions were more frequent on the side of the animal experimentally infected with the virus.
Lesions were more severe in lambs than in goats, suggesting that lambs may be more susceptible
to SGEV, which may be due to species di erences or to interindividual di erences in the immune
response, rather than to di erences in the relative proportions of immune cells. Larger studies that
monitor natural or experimental infections may help clarify local immune responses to this flavivirus
subtype in the central nervous system.
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/RTI2018-096010-B-C21/ES/EL TEJON (MELES MELES) Y LA TUBERCULOSIS ANIMAL EN ESPAÑA: INTERACCION TEJON-BOVINO EN HOTSPOT AREAS Y MEDIDAS DE CONTROL DE LA ENFERMEDAD EN LA INTERFASE
URI
DOI
Versión del editor
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