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Título
Genetic Characterization and Phylogenetic Analysis of Small Ruminant Lentiviruses Detected in Spanish Assaf Sheep with Different Mammary Lesions
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Viruses
Número de la revista
6
Datos de la obra
Gayo, E., Cuteri, V., Polledo, L., Rossi, G., García Marín, J. F., & Preziuso, S. (2018). Genetic characterization and phylogenetic analysis of small ruminant lentiviruses detected in Spanish Assaf sheep with different mammary lesions. Viruses, 10(6), Article e315. https://doi.org/10.3390/V10060315
Editor
MDPI
Fecha
2018
Abstract
[EN]Small Ruminant Lentiviruses (SRLVs) are widespread in many countries and cause economically relevant, slow, and persistent diseases in sheep and goats. Monitoring the genetic diversity of SRLVs is useful to improve the diagnostic tools used in the eradication programs. In this study, SRLVs detected in Spanish Assaf sheep with different grades of lymphoproliferative mastitis were sequenced. Genetic characterization showed that most samples belonged to type A and were closer to Spanish SRLV isolates previously classified as A2/A3. Four samples belonged to subtype B2 and showed higher homology with Italian B2 strains than with Spanish B2 isolates. Amino acid sequences of immuno-dominant epitopes in the gag region were very conserved while more alterations were found in the LTR sequences. No significant correlations were found between grades of mastitis and alterations in the sequences although samples with similar histological features were phylogenetically closer to each other. Broader genetic characterization surveys in samples with different grades of SRLV-lesions are required for evaluating potential correlations between SRLV sequences and the severity of diseases.
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/MECD/Programa Estatal de Promoción del Talento y su Empleabilidad/FPU13/01081
URI
DOI
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