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Título
Analysis of cardiovascular risk factors for the viability of cornea donors: a case–control study
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
BMJ Open
Número de la revista
12
Cita Bibliográfica
Montero-Salinas, A., Martínez-Isasi, S., Fieira-Costa, E., Suanzes-Hernández, J., Fernández-García, D., Gómez-Salgado, J., & Rendal-Vazquez, E. (2023). Analysis of cardiovascular risk factors for the viability of cornea donors: A case-control study. BMJ Open, 13(12). https://doi.org/10.1136/BMJOPEN-2023-077122
Editorial
BMJ
Fecha
2023
ISSN
2044-6055
Resumen
[EN] Objective The main objective of the study was to
evaluate the influence of arterial hypertension, diabetes,
dyslipidaemia, smoking, alcoholism and COPD (chronic
obstructive pulmonary disease) on the viability of the
extracted tissue as well as the donor.
Design Observational case–control study.
Setting Regional hospital in Northern Spain.
Participants 1517 corneas were registered.
Interventions Patients’ medical history was reviewed
after corneal donation and evaluation. Previous medical
information (age, sex and cardiovascular risk factors
(CVRFs)) and data related to the donor (type of donor), the
corneal tissue and its evaluation, and the viability of the
implant were collected.
Results A total of 1517 corneas were registered and
81.5% of the donors presented at least one CVRF. In
relation to the viability of the donor, it was observed that
having suffered from COPD reduced the viability of the
donor (no COPD: 93.8% vs COPD: 88%; OR=0.49; 95%
CI: 0.28 to 0.84) while alcohol consumption increased
it (drinker or ex-drinker: 95.8% vs non-drinker: 92.5%;
OR=1.84; 95% CI: 1.01 to 3.33). Regarding tissue viability,
decreased viability was observed in the presence of
COPD (no COPD: 72.5% vs COPD: 64; OR=0.67; 95% CI:
0.47 to 0.96) and diabetes mellitus (no diabetes: 72.9%
vs diabetes: 67.2%; OR=0.76; 95% CI: 0.58 to 0.99). As
regards the viability of the implant, a total of 1039 corneas
(68.9%) were suitable, observing decreased viability when
suffering from COPD (no COPD: 69.8% vs COPD: 60.7%;
OR=0.67; 95% CI: 0.47 to 0.94) and increased when
having an active smoking habit (no habit: 65.3% vs habit:
74.1%; OR=1.52; 95% CI: 1.21 to 1.91).
Conclusions Through this study, it can be concluded that
in the absence of absolute exclusion criteria for donors, the
assessment of how CVRF, alcoholism and COPD may affect
the donor provides details about the quality of the tissue to
be obtained.
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