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Título
Study of the pharmacokinetic interaction between ethinylestradiol and amoxicillin in rabbits
Autor
Facultad/Centro
Área de conocimiento
Cita Bibliográfica
Contraception, 1997, n. 55
Editorial
Elsevier
Fecha
1997-09-20
Resumen
Several antibiotics have been implicated in oral contraception failure when they are administered at the same time as the oral contraceptive (OC) pill. In the present paper, a study about amoxicillin-ethinylestradiol (EE22 pharmacokinetic potential interaction was studied. Two rabbit groups were utilized, the first group received amoxicillin (10 mg/kg) and EE 22 (30, 50 and 100 µg/kg, respectively), both by intravenous (i.v.) route. The second group received amoxicillin (oral route, 10 mg/kg/day) and EE 22 (i.v. route, 100 µ/kg) on day 1,4 and 8 of antibiotic treatment, respectively. After compartmental (two-compartment open model) and non-compartmental analysis of plasma concentrations, the statistical study (ANOVA p< 0.05) revealed that the presence of amoxicillin did not modify the EE 22 distribution and elimination pharmacokinetic parameters (by comparison with those obtained in a previous stud y where E22 was administered alone). There also were no significant differences with the time of amoxicillin oral treatment.
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