dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | García, Juan J. | |
dc.contributor.author | Diez Liébana, María José | |
dc.contributor.author | Sierra Vega, Matilde | |
dc.contributor.author | Terán Somaza, María Teresa | |
dc.contributor.other | Farmacologia | es_ES |
dc.date | 1992-01-08 | |
dc.date.accessioned | 2015-09-04T11:41:32Z | |
dc.date.available | 2015-09-04T11:41:32Z | |
dc.date.issued | 2015-09-04 | |
dc.identifier.citation | Journal of Veterinary Pharmacology and Therapeutics, 1992, n. 15 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10612/4576 | |
dc.description | P. 85-90 | es_ES |
dc.description.abstract | A compartmental and non-compartmental pharmacokinetic study was carried out on rabbits after intravenous (i.v.) administration of levamisole al the three dose rales: 12.5. 16.0 and 20.0 mg/kg body weight. Using compartmental analysis, the disposition of levamisole best fitted a t wo-compartmental open model with mean values of α= 0.1278, 0. 1019 and 0.1282 mi n - 1 ; β =0.0139
O.O 126 and 0.0124 min- 1 ; A = 6 .24. 5.27 and 10.58 µg/ml and β = 2.14. :3083
and 5.08 µg/ml for each dose, respectively. The statistical moment theory was mainly used for non-compartmental analysis. Values for mean residence time (MRT) of 69.2, 71 .7 and 73. 1 min were obtained for each dose. The mean values for volume of dist ribution at steady state ( Vd(ss)). determined by compartmental analysis, were 3879. 3 279 and 2735 ml/kg for each dose. and values obtained using the statistical moment theory were :3760. 3015 and 2943 ml/kg; there were no statistically significant differences using Student's paired 1-lest. Identical conclusions were obtained using both methods when the parameters β. AUC and Cl were compared. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.subject | Ecología. Medio ambiente | es_ES |
dc.subject | Farmacología | es_ES |
dc.subject | Veterinaria | es_ES |
dc.subject.other | Pharmacokinetics | es_ES |
dc.subject.other | Levamisole | es_ES |
dc.subject.other | Intravenous administration | es_ES |
dc.subject.other | Rabbits | es_ES |
dc.title | Pharmacokinetics of levamisole in rabbits after intravenous administration | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.peerreviewed | SI | es_ES |