RT info:eu-repo/semantics/article
T1 Mitochondrial function and mitophagy in the elderly: effects of exercise
A1 Costa Moreira, Osvaldo
A1 Estébanez González, Brisamar
A1 Martínez Flórez, Susana
A1 Paz Fernández, José Antonio de
A1 Cuevas González, María José
A1 González Gallego, Javier
A2 Fisiologia
K1 Fisiología
K1 envejecimiento
K1 función mitocondrial
K1 mitofagia
K1 ejercicio físico
K1 tercera edad
K1 2410 Biología Humana
K1 2402.15 Envejecimiento Somático
AB [EN] Aging is a natural, multifactorial and multiorganic phenomenon wherein there are gradual physiological and pathological changes over time. Aging has been associated with a decrease of autophagy capacity and mitochondrial functions, such as biogenesis, dynamics, and mitophagy. These processes are essential for the maintenance of mitochondrial structural integrity and, therefore, for cell life, since mitochondrial dysfunction leads to an impairment of energy metabolism and increased production of reactive oxygen species, which consequently trigger mechanisms of cellular senescence and apoptotic cell death. Moreover, reduced mitochondrial function can contribute to age-associated disease phenotypes in model organisms and humans. Literature data show beneficial effects of exercise on the impairment of mitochondrial biogenesis and dynamics and on the decrease in the mitophagic capacity associated to aging. Thus, exercise could have effects on the major cell signaling pathways that are involved in the mitochondria quality and quantity control in the elderly. Although it is known that several exercise protocols are able to modify the activity and turnover of mitochondria, further studies are necessary in order to better identify the mechanisms of interaction between mitochondrial functions, aging, and physical activity, as well as to analyze possible factors influencing these processes.
PB Hindawi
SN 1942-0900
LK https://hdl.handle.net/10612/17644
UL https://hdl.handle.net/10612/17644
NO Moreira, O. C., Estébanez, B., Martínez-Florez, S., De Paz, J. A., Cuevas, M. J., & González-Gallego, J. (2017). Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise [Review of Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise]. Oxidative Medicine and Cellular Longevity, 2017. Hindawi Limited. https://doi.org/10.1155/2017/2012798
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 18-jun-2024