RT info:eu-repo/semantics/article
T1 Resistance training diminishes the expression of exosome CD63 protein without modification of plasma miR-146a-5p and cfDNA in the elderly
A1 Estébanez González, Brisamar
A1 Visavadiya, Nishant P.
A1 Paz Fernández, José Antonio de
A1 Whitehurst, Michael
A1 Cuevas González, María José
A1 González Gallego, Javier
A1 Huang, Chun-Jung
A2 Fisiologia
K1 Fisiología
K1 Aging
K1 Cell-free DNA
K1 Exercise-promoted exosomes
K1 Extracellular vesicles
K1 Inflammaging
K1 MicroRNAs
K1 Physical activity
K1 Strength training
K1 3201.07 Geriatría
K1 3201 Ciencias Clínicas
AB [EN] Aging-associated inflammation is characterized by senescent cell-mediated secretion of high levels of inflammatory mediators, such as microRNA (miR)-146a. Moreover, a rise of circulating cell-free DNA (cfDNA) is also related to systemic inflammation and frailty in the elderly. Exosome-mediated cell-to-cell communication is fundamental in cellular senescence and aging. The plasma changes in exercise-promoted miR-146a-5p, cfDNA, and exosome release could be the key to facilitate intercellular communication and systemic adaptations to exercise in aging. Thirty-eight elderly subjects (28 trained and 10 controls) volunteered in an 8-week resistance training protocol. The levels of plasma miR-146a-5p, cfDNA, and exosome markers (CD9, CD14, CD63, CD81, Flotillin [Flot]-1, and VDAC1) were measured prior to and following training. Results showed no changes in plasma miR-146a-5p and cfDNA levels with training. The levels of exosome markers (Flot-1, CD9, and CD81) as well as exosome-carried proteins (CD14 and VDAC1) remained unchanged, whereas an attenuated CD63 response was found in the trained group compared to the controls. These findings might partially support the anti-inflammatory effect of resistance training in the elderly as evidenced by the diminishment of exosome CD63 protein expression, without modification of plasma miR-146a-5p and cfDNA.
PB MDPI
LK https://hdl.handle.net/10612/17670
UL https://hdl.handle.net/10612/17670
NO Estébanez, B., Visavadiya, N. P., de Paz, J. A., Whitehurst, M., Cuevas, M. J., González-Gallego, J., & Huang, C.-J. (2021). Resistance training diminishes the expression of exosome cd63 protein without modification of plasma mir-146a-5p and cfdna in the elderly. Nutrients, 13(2), 1-13. https://doi.org/10.3390/NU13020665
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 09-jun-2024