RT info:eu-repo/semantics/article
T1 Distribution of flumequine in intestinal contents and colon tissue in pigs after its therapeutic use in the drinking water
A1 Rodríguez Lago, José Manuel
A1 Diez Liébana, María José
A1 Sierra Vega, Matilde
A1 Fernández Martínez, María Nélida
A1 Díez Láiz, Raquel
A1 Sahagún Prieto, Ana María
A1 García Viéitez, Juan José
A2 Farmacologia
K1 Farmacología
K1 Veterinaria
K1 Colon tissue
K1 Flumequine
K1 Intestinal content
K1 Pig
K1 HPLC
K1 Plasma
K1 3109 Ciencias Veterinarias
K1 3109.08 Farmacología
K1 Oral administration
AB [EN] Flumequine concentrations in plasma, colon tissue and intestinal contents were evaluated in 12 healthy pigs after oral administration (12 mg/kg every 24 h for 5 consecutive days in drinking water). Plasma, colon tissue and intestinal content samples were collected from animals sacrificed on days 3, 6 and 7. Concentrations were measured by high performance liquid chromatography after having validated the method, following the European Medicines Agency (EMA) requirements. The drug was not detected in any plasma sample. In colon tissue, concentrations were higher on day 3 (0.230 ± 0.033 µg/g, descending colon; 0.156 ± 0.093 µg/g, ascending colon) than on day 6 (0.187 ± 0.123 µg/g, descending colon; 0.107 ± 0.007 µg/g, ascending colon). Concentrations were considerably higher in intestinal contents, again on day 3 (1.349 ± 1.401 µg/g, descending colon; 0.591 ± 0.209 µg/g, ascending colon) than on days 6 (0.979 ± 0.346 µg/g, descending colon; 0.595 ± 0.075 µg/g, ascending colon) and 7 (0.247 ± 0.172 µg/g, descending colon; 0.172 ± 0.086 µg/g, ascending colon). Measured concentrations were lower than those effective against the most common intestinal pathogenic microorganisms in swine and, more specifically, Brachyspira hyodysenteriae.
PB MDPI
LK https://hdl.handle.net/10612/17700
UL https://hdl.handle.net/10612/17700
NO Rodríguez, J. M., Diez, M. J., Sierra, M., Garcia, J. J., Fernandez, N., Diez, R., & Sahagun, A. M. (2021). Distribution of flumequine in intestinal contents and colon tissue in pigs after its therapeutic use in the drinking water. Animals, 11(6). https://doi.org/10.3390/ANI11061514
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 20-may-2024