RT info:eu-repo/semantics/article
T1 Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High‐Fat Diet Determine Non‐Alcoholic Fatty Liver Disease Development in Germ‐Free Mice
A1 Porras Sanabria, David
A1 Nistal González, Maria Esther
A1 Martínez Flórez, Susana
A1 Olcoz Goñi, José Luis
A1 Jover Atienza, Ramiro
A1 Jorquera, F.
A1 González Gallego, Javier
A1 García Mediavilla, María Victoria
A1 Sánchez Campos, Sonia
A2 Fisiologia
K1 Fisiología
K1 Akkermansia spp
K1 Flavonoids
K1 Gut microbiota transplantation
K1 Gut-liver axis
K1 Nonalcoholic fatty liver disease
K1 2411 Fisiología Humana
AB [EN] Scope: Modulation of intestinal microbiota has emerged as a new therapeutic approach for non-alcoholic fatty liver disease (NAFLD). Herein, it is addressed whether gut microbiota modulation by quercetin and intestinal microbiota transplantation can influence NAFLD development. Methods and results: Gut microbiota donor mice are selected according to their response to high-fat diet (HFD) and quercetin in terms of obesity and NAFLD-related biomarkers. Germ-free recipients displayed metabolic phenotypic differences derived from interactions between microbiota transplanted, diets, and quercetin. Based on the evaluation of hallmark characteristics of NAFLD, it is found that gut microbiota transplantation from the HFD-non-responder donor and the HFD-fed donor with the highest response to quercetin results in a protective phenotype against HFD-induced NAFLD, in a mechanism that involves gut–liver axis alteration blockage in these receivers. Gut microbiota from the HFD-responder donor predisposed transplanted germ-free mice to NAFLD. Divergent protective and deleterious metabolic phenotypes exhibited are related to definite microbial profiles in recipients, highlighting the predominant role of Akkermansia genus in the protection from obesity-associated NAFLD development. Conclusions: The results provide scientific support for the prebiotic capacity of quercetin and the transfer of established metabolic profiles through gut microbiota transplantation as a protective strategy against the development of obesity-related NAFLD
PB Wiley
SN 1613-4125
LK https://hdl.handle.net/10612/17922
UL https://hdl.handle.net/10612/17922
NO Porras, D., Nistal González, E., Martínez-Flórez, S., Olcoz, J. L., Jover, R., Jorquera, F., González-Gallego, J., García-Mediavilla, M. V., & Sánchez-Campos, S. (2019). Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High-Fat Diet Determine Non-Alcoholic Fatty Liver Disease Development in Germ-Free Mice. Molecular Nutrition and Food Research, 63(8). https://doi.org/10.1002/MNFR.201800930
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 15-jun-2024