RT info:eu-repo/semantics/article
T1 Identification of Candidate Genes for Reactivity in Guzerat (Bos indicus) Cattle: A Genome-Wide Association Study
A1 Dos Santos, Fernanda Caroline
A1 Diniz Peixoto, Maria Gabriela Campolina
A1 De Souza Fonseca, Pablo Augusto
A1 Ávila Pires, Maria de Fátima
A1 Vieira Ventura, Ricardo
A1 Da Cruz Rosse, Izinara
A1 Tomita Bruneli, Frank Angelo
A1 Machado, Marco Antonio
A1 Santos Carvalho, Maria Raquel
A2 Producción Animal
K1 Genética
K1 GWAS
K1 Temperament
K1 Cattle
K1 3109 Ciencias Veterinarias
K1 3109.02 Genética
AB [EN] Temperament is fundamental to animal production due to its direct influence on the animalherdsman relationship. When compared to calm animals, the aggressive, anxious or fearful ones exhibit less weight gain, lower reproductive efficiency, decreased milk production and higher herd maintenance costs, all of which contribute to reduced profits. However, temperament is a trait that is complex and difficult to assess. Recently, a new quantitative system, REATEST®, for assessing reactivity, a phenotype of temperament, was developed. Herein, we describe the results of a Genome-wide association study for reactivity, assessed using REATEST® with a sample of 754 females from five dual-purpose (milk and meat production) Guzerat (Bos indicus) herds. Genotyping was performed using a 50k SNP chip and a twostep mixed model approach (Grammar-Gamma) with a one-by-one marker regression was used to identify QTLs. QTLs for reactivity were identified on chromosomes BTA1, BTA5, BTA14, and BTA25. Five intronic and two intergenic markers were significantly associated with reactivity. POU1F1, DRD3, VWA3A, ZBTB20, EPHA6, SNRPF and NTN4 were identified as candidate genes. Previous QTL reports for temperament traits, covering areas surrounding the SNPs/genes identified here, further corroborate these associations. The seven genes identified in the present study explain 20.5% of reactivity variance and give a better understanding of temperament biology. Introduction
PB Plos
LK https://hdl.handle.net/10612/17928
UL https://hdl.handle.net/10612/17928
NO Dos Santos, F. C., Peixoto, M. G. C. D., Fonseca, P. A. D. S., Pires, M. D. F. Á., Ventura, R. V., Rosse, I. D. C., ... & Carvalho, M. R. S. (2017). Identification of candidate genes for reactivity in guzerat (Bos indicus) cattle: a genome-wide association study. PLoS One, 12(1), e0169163.
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 10-jun-2024