RT info:eu-repo/semantics/article
T1 Occupational Heat Exposure and Breast Cancer Risk in the MCC-Spain Study
A1 Hinchliffe, Alice
A1 Kogevinas, Manolis
A1 Pérez Gómez, Beatriz
A1 Ardanaz, Eva
A1 Amiano, Pilar
A1 Marcos Delgado, Alba
A1 Castaño Vinyals, Gemma
A1 Llorca, Javier
A1 Moreno, Víctor
A1 Alguacil, Juan
A1 Fernández Tardón, Guillermo
A1 Salas, Dolores
A1 Marcos Gragera, Rafael
A1 Aragonés, Nuria
A1 Guevara, Marcela
A1 Gil, Leire
A1 Martín Sánchez, Vicente
A1 Benavente, Yolanda
A1 Gómez Acebo, Inés
A1 Santibáñez, Miguel
A1 Alba, Miguel Ángel
A1 García, Ana M.
A1 Pollán, Marina
A1 Turner, Michelle C.
A2 Medicina Preventiva
K1 Medicina. Salud
K1 Shock proteins
K1 Pancreatic-cancer
K1 Aluminum smelter
K1 Workers
K1 Stress
K1 Factor-1
K1 Health
AB [EN] Background: Mechanisms linking occupational heat exposure with chronic diseases have been proposed. However, evidence on occupational heat exposure and cancer risk is limited. Methods: We evaluated occupational heat exposure and female breast cancer risk in a large Spanish case-control study. We enrolled 1,738 breast cancer cases and 1,910 frequency-matched population controls. A Spanish job-exposure matrix, MatEmEsp, was used to assign estimates of the proportion of workers exposed (P >= 25% for at least 1 year) and work time with heat stress (wet bulb globe temperature ISO 7243) for each occupation. We used three exposure indices: ever versus never exposed, lifetime cumulative exposure, and duration of exposure (years). We estimated ORs and 95% confidence intervals (CI), applying a lag period of 5 years and adjusting for potential confounders. Results: Ever occupational heat exposure was associated with a moderate but statistically significant higher risk of breast cancer (OR 1.22; 95% CI, 1.01-1.46), with significant trends across categories of lifetime cumulative exposure and duration (P-trend = 0.01 and 0.03, respectively). Stronger associations were found for hormone receptor-positive disease (OR ever exposure = 1.38; 95% Cl, 1.12-1.67). We found no confounding effects from multiple other common occupational exposures; however, results attenuated with adjustment for occupational detergent exposure. Conclusions: This study provides some evidence of an association between occupational heat exposure and female breast cancer risk.
PB American Association of Cancer Research
SN 1055-9965
LK https://hdl.handle.net/10612/18195
UL https://hdl.handle.net/10612/18195
NO Hinchliffe, A., Kogevinas, M., Pérez Gómez, B., Ardanaz, E., Amiano, P., Marcos Delgado, A., Castaño Vinyals, G., Llorca, J., Moreno, V., Alguacil, J., Fernández Tardón, G., Salas, D., Marcos Gragera, R., Aragonés, N., Guevara, M., Gil, L., Martín Sánchez, V., Benavente, Y., Gómez Acebo, I., Santibáñez, M.  (2021). Occupational heat exposure and breast cancer risk in the MCC-Spain study. Cancer Epidemiology, Biomarkers & Prevention, 30(2), 364-372. https://doi.org/10.1158/1055-9965.EPI-20-0732
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 19-may-2024