RT info:eu-repo/semantics/article
T1 Relationship between Aldehyde Dehydrogenase, PD-L1 and Tumor-Infiltrating Lymphocytes with Pathologic Response and Survival in Breast Cancer
A1 López Flores, Mariana Alejandra
A1 Honrado Franco, Emiliano
A1 Sánchez Cousido, Luis Felipe
A1 Minguito Carazo, Carlos
A1 Sanz Guadarrama, Oscar
A1 López González, Laura
A1 Vallejo Pascual, María Eva
A1 Molina de la Torre, Antonio José
A1 García Palomo, Andrés
A1 López González, Ana
A2 Métodos Cuantitativos para la Economía y la Empresa
K1 Estadística
K1 Medicina. Salud
K1 Aldehyde dehydrogenase;
K1 Breast cancer stem cells
K1 Breast cancer
AB [EN] Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell (CSC) marker relatedto clinical outcomes in breast cancer (BC). The aim of this study was to analyze the relationshipbetween ALDH1A1, programmed death ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs)in triple negative (TN) and human epidermal growth factor receptor 2-positive (HER2+) BC tumors,and its association with clinicopathological characteristics and outcomes. A retrospective, historicalcohort study of patients diagnosed with early or locally advanced BC treated with neoadjuvantchemotherapy was conducted. ALDH1A1, PD-L1 expression and TILs were assessed using immunohistochemistry.A total of 75 patients were analyzed (42.7% TN, 57.3% HER2+ tumors). ALDH1A1+was related to HTILs (p = 0.005) and PD-L1+ tumors (p = 0.004). ALDH1A1+ tumors presentedhigher CD3+ (p = 0.008), CD4+ (p = 0.005), CD8+ (p = 0.003) and CD20+ (p = 0.006) TILs. ALDH1A1+(p = 0.018), PD-L1+ (p = 0.004) and HTILs (p < 0.001) were related to smaller tumors. ALDH1A1+was related to pathologic complete response (pCR) (p = 0.048). At the end of the follow-up (54.4[38.3–87.6] months), 47 patients (62.7%) remained disease-free, and 20 (26.7%) had died. HTILs wererelated to improved disease-free survival (p = 0.027). ALDH1A1+ was related to PD-L1+ and HITLs,that might be related to higher pCR rates with neoadjuvant therapy.
PB MDPI
LK https://hdl.handle.net/10612/18413
UL https://hdl.handle.net/10612/18413
NO López Flores, M., Honrado Franco, E., Sánchez Cousido, L. F., Minguito-Carazo, C., Sanz Guadarrama, O., López González, L., Vallejo Pascual, M. E., Molina de la Torre, A. J., García Palomo, A., y López González, A. (2022). Relationship between Aldehyde Dehydrogenase, PD-L1 and Tumor-Infiltrating Lymphocytes with Pathologic Response and Survival in Breast Cancer. Cancers, 14(18). https://doi.org/10.3390/CANCERS14184418
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 01-jun-2024