RT info:eu-repo/semantics/article
T1 The local skin cellular immune response determines the clinical outcome of sarcoptic mange in Iberian ibex (Capra pyrenaica)
A1 Valldeperes, Marta
A1 Granados, José Enrique
A1 Pérez Pérez, Valentín
A1 López Olvera, Jorge Ramón
A1 Ráez Bravo, Arián
A1 Fandos, Paulino
A1 Pérez, Jesús M.
A1 Mentaberre, Gregorio
A1 Tampach, Stefania
A1 Soriguer, Ramón C.
A1 Espinosa Cerrato, José
A2 Sanidad Animal
K1 Sanidad animal
K1 Capra pyrenaica
K1 Clinical outcome
K1 Experimental infestation
K1 Iberian ibex
K1 Immunohistochemistry
K1 Inflammatory cell
K1 Sarcoptic mange (Sarcoptes scabiei)
K1 Skin immune response
K1 3109 Ciencias Veterinarias
AB [EN] Introduction: Sarcoptic mange, caused by Sarcoptes scabiei, is a disease with implications for wildlife conservation and management. Its severity depends on the host’s local skin immune response, which is largely unknown in Iberian ibex (Capra pyrenaica), a mountain ungulate dramatically affected by mange. In this species, the clinical outcome of sarcoptic mange varies among individuals, and the local immune response could be key to controlling the infestation. This study aims to characterize the local cellular immune response and its relationship with the clinical outcome. Methods: Fourteen Iberian ibexes were experimentally infested with S. scabiei and six more served as controls. Clinical signs were monitored, and skin biopsies were collected from the withers at 26, 46, and 103 days post-infection (dpi). The presence and distribution of macrophages (including M1 and M2 phenotypes), T lymphocytes, B lymphocytes, plasma cells, and interleukine 10 were quantitatively evaluated using immunohistochemical techniques. Results: An inflammatory infiltrate that decreased significantly from 26 to 103 dpi was observed in all the infested ibexes. The predominant inflammatory cell population in the skin of the mangy ibexes was formed by macrophages (mainly the M2 phenotype) followed by T lymphocytes, with lower numbers of B lymphocytes and plasma cells. Three clinical courses were identified: total recovery, partial recovery, and terminal stage. The inflammatory infiltrates were less pronounced in the fully recovered ibexes than in those that progressed to the terminal stage throughout the study. Discussion: The results suggest an exacerbated but effective Th1-type cellular immune response controlling mange in Iberian ibex. Furthermore, the local immune response appears to determine the variability of the clinical responses to S. scabiei infestation in this species. This first report on the progression of local skin immune cells is relevant not only for individuals but also for population management and conservation.
PB Frontiers Media
LK https://hdl.handle.net/10612/18685
UL https://hdl.handle.net/10612/18685
NO Valldeperes, M., Granados, J. E., Pérez, V., López-Olvera, J. R., Ráez-Bravo, A., Fandos, P., Pérez, J. M., Mentaberre, G., Tampach, S., Soriguer, R. C., & Espinosa, J. (2023). The local skin cellular immune response determines the clinical outcome of sarcoptic mange in Iberian ibex (Capra pyrenaica). Frontiers in Veterinary Science, 10. https://doi.org/10.3389/FVETS.2023.1183304
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 11-jun-2024