RT info:eu-repo/semantics/article
T1 Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study
A1 Moroni, Barbara
A1 Granados Torres, José Enrique
A1 López Olvera, Jorge Ramón
A1 Espinosa Cerrato, José
A1 Ráez Bravo, Arián
A1 Mentaberre, Gregorio
A1 Fandos, Paulino
A1 Pazzi, Marco
A1 Romagnoli, Monica
A1 Gardini, Giulia
A1 Rossi, Luca
A1 Valldeperes, Marta
A1 Serrano, Emmanuel
A1 Ramos, Blanca
A1 Odore, Rosangela
A2 Sanidad Animal
K1 Sanidad animal
K1 Ivermectin
K1 Sarcoptic mange
K1 Wildlife
K1 Iberian ibex
K1 Treatment
K1 Medicated feed
K1 3109 Ciencias Veterinarias
AB [EN] Sarcoptic mange is considered the main driver of demographic declines occurred in the last decades in Iberian ibex (Capra pyrenaica) populations. Mass treatment campaigns by administration of in-feed acaricides are used as a measure to mitigate the impact of mange in the affected populations. However, there are no data on ivermectin (IVM) pharmacokinetics in this wild caprine, and the treatment through medicated feed is not endorsed by evidence on its effectiveness. The aim of this study is to determine the pharmacokinetic profile of IVM in plasma samples of ibexes after the experimental oral administration of IVM, using high performance liquid chromatography (HPLC) with automated solid phase extraction and fluorescence detection. A dose of 500 μg of IVM per body weight was orally administered in a feed bolus to nine healthy adult ibexes (seven males and two females). Blood samples were collected by jugular venipuncture into heparin-coated tubes at day 1, 2, 3, 4, 7, 10, 15, and 45 post-administration (dpa). The highest plasma concentration of IVM (Cmax = 3.4 ng/ml) was detected 24 h after the oral administration (T1), followed by a rapid decrease during the first week post-administration. Our results reveal that plasma IVM concentration drops drastically within 5 days of ingestion, questioning the effectiveness of a single in-feed dose of this drug to control sarcoptic mange. To the best of our knowledge, this is the first study on plasma availability of oral IVM in ibexes and in any wild ungulate species.
PB Frontiers Media
LK https://hdl.handle.net/10612/18802
UL https://hdl.handle.net/10612/18802
NO Moroni, B., Granados Torres, J. E., López-Olvera, J. R., Espinosa Cerrato, J., Ráez Bravo, A., Mentaberre, G., Fandos, P., Pazzi, M., Romagnoli, M., Gardini, G., Rossi, L., Valldeperes, M., Serrano, E., Ramos, B., & Odore, R. (2022). Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study. Frontiers in Veterinary Science, 9. https://doi.org/10.3389/FVETS.2022.830157
NO Copyright © 2022 Moroni, Granados Torres, López-Olvera, Espinosa Cerrato, Ráez Bravo, Mentaberre, Fandos, Pazzi, Romagnoli, Gardini, Rossi, Valldeperes, Serrano, Ramos and Odore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 10-jun-2024