RT info:eu-repo/semantics/article
T1 Novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by Haemonchus contortus
A1 Valderas García, Elora
A1 Escala, Nerea
A1 Álvarez Bardón, María
A1 Castilla Gómez de Agüero, Verónica
A1 Cambra Pellejà, Maria
A1 González del Palacio, Laura
A1 Vallejo García, Raquel
A1 de la Vega, Jennifer
A1 San Feliciano Martín, Arturo
A1 del Olmo, Esther
A1 Martínez Valladares, María
A1 Balaña Fouce, Rafael
A2 Sanidad Animal
K1 Sanidad animal
K1 Haemonchus contortus
K1 Small ruminants
K1 Gastrointestinal nematodes
K1 3109 Ciencias Veterinarias
AB [EN] The control of gastrointestinal nematodes in livestock is becoming increasingly difficult due to the limited number of available drugs and the rapid development of anthelmintic resistance. Therefore, it is imperative to develop new anthelmintics that are effective against nematodes. Under this context, we tested the potential toxicity of three compounds in mice and their potential anthelmintic efficacy in Mongolian gerbils infected with Haemonchus contortus. The compounds were selected from previous in vitro experiments: two diamine (AAD-1 and AAD-2) and one benzimidazole (2aBZ) derivatives. 2aBZ was also selected to test its efficacy in sheep. In Mongolian gerbils, the benzimidazole reduced the percentage of pre-adults present in the stomach of gerbils by 95% at a dose of 200 mg/kg. In sheep, there was a 99% reduction in the number of eggs shed in faeces after 7 days at a dose of 120 mg/kg and a 95% reduction in the number of worm adults present in the abomasum. In conclusion, 2aBZ could be considered a promising candidate for the treatment of helminth infections in small ruminants
PB Nature Research
LK https://hdl.handle.net/10612/18808
UL https://hdl.handle.net/10612/18808
NO Valderas-García, E., Escala, N., Álvarez-Bardón, M., Castilla-Gómez de Agüero, V., Cambra-Pellejà, M., González del Palacio, L., Vallejo García, R., de la Vega, J., San Feliciano, A., del Olmo, E., Martínez-Valladares, M., & Balaña-Fouce, R. (2022). Novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by Haemonchus contortus. Scientific Reports, 12(1). https://doi.org/10.1038/S41598-022-17112-3
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 07-jun-2024