RT info:eu-repo/semantics/article
T1 Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 Screening
A1 Martín Sánchez, Vicente
A1 Fernández Villa, Tania
A1 Carvajal Urueña, Ana María
A1 Rivero Rodríguez, Ana María
A1 Reguero Celada, Sofía
A1 Sánchez Antolín, Gloria
A1 Fernández Vázquez, José Pedro
A2 Sanidad Animal
K1 Sanidad animal
K1 SARS-CoV-2
K1 Screening
K1 Antigen
K1 5312.07 Sanidad
K1 32 Ciencias Médicas
K1 3202 Epidemiología
AB [EN] This study evaluates a population‐based screening of asymptomatic people, using a rapid antigen diagnostic test (RADT), in areas of high transmission. To detect sources of SARS‐CoV‐2 infection, nasopharyngeal samples were taken and were tested using RADT. Confirmatory RT-qPCR tests were performed in both positive and negative cases. The internal validity of the RADT, the prevalence of infection, and the positive and negative predictive values (PPV and NPV) were estimated, based on the percentages of confirmed cases with 95% confidence interval.. Of the 157,920 people registered, 50,492 participated in the screening; 50,052 were negative, and 440 were positive on the RADT (0.87%). A total of 221 positive RADT samples were reanalysed using RT-qPCR and 214 were confirmed as positive (96.8%; 95% CI: 93.5–98.7%), while 657 out of 660 negative RADT samples were confirmed as RT‐qPCR negative (99.5%; 95% CI 98.7–99.9%). The sensitivity obtained was 65.1% (38.4–90.2%) and the specificity was 99.97% (99.94–99.99%). The prevalence of infection was 1.30% (0.95–2.13%). The PPVs were 95.4% (85.9–98.9%) and 97.9% (93.3–99.5%), respectively, while the NPVs were 99.7% (99.4–100%) and 99.2% (98.7–100%), respectively. The high specificity found allow us to report a high screening performance in asymptomatic patients, even in areas where the prevalence of infection was less than 2%.
PB MDPI
LK https://hdl.handle.net/10612/18912
UL https://hdl.handle.net/10612/18912
NO Martín‐sánchez, V., Fernández‐villa, T., Carvajal Urueña, A., Rivero Rodríguez, A., Reguero Celada, S., Sánchez Antolín, G., & Fernández‐vázquez, J. P. (2021). Role of rapid antigen testing in population‐based sars‐cov‐2 screening. Journal of Clinical Medicine, 10(17). https://doi.org/10.3390/JCM10173854
NO Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 07-jun-2024