RT info:eu-repo/semantics/article
T1 Effects of a low-fat diet with antioxidant supplementation on biochemical markers of multiple sclerosis long-term care residents
T2 EFECTO DE UNA DIETA BAJA EN GRASAS CON SUPLEMENTACIÓN DE ANTIOXIDANTES EN LOS MARCADORES BIOQUÍMICOS DE RESIDENTES DE LARGA ESTANCIA CON ESCLEROSIS MÚLTIPLE
A1 Mauriz García, Elba
A1 Laliena Izquierdo, Almudena
A1 Vallejo, Daniela
A1 Tuñón González, María Jesús
A1 Rodríguez López, Jesús María
A1 Rodríguez Pérez, Roberto
A1 García Fernández, María del Camino
A2 Enfermeria
K1 Enfermería
K1 Dieta baja en grasas
K1 Suplementos antioxidantes
K1 Esclerosis múltiple
K1 Verbascósido
K1 3309.28 Aceites y Grasas Vegetales
K1 3212 Salud Publica
K1 2302 Bioquímica
K1 3205 Medicina Interna
AB [EN] Introduction: Multiple sclerosis (MS) treatment options are primarily limited to immunomodulatory therapies in MS non-progressive forms. Nutrition intervention studies suggest that diet may be considered as a complementary treatment to control disease progression. Therefore, dietary intervention may help to improve wellness and ameliorate symptoms of MS patients. Objectives: To assess the effect of a low-fat diet with antioxidant supplementation on biochemical markers of institutionalized patients with progressive forms of multiple sclerosis. Methods: A randomized prospective placebo-controlled study involving 9 participants, 5 of them assigned to the intervention group (low-fat diet and antioxidant supplementation) and the other 4 to the placebo group (low-fat diet). The effect of the dietary intervention, involving diet modification and antioxidant supplementation, was examined for 42 days by measuring anthropometric, biochemical parameters and oxidative stress markers in blood at baseline (day 0), intermediate (day 15) and end (day 42) stages of the treatment. Results: The intervention group obtained C reactive protein levels significantly lower than those observed in the corresponding placebo group at the end of the study. Oxidative stress and inflammatory markers isoprostane 8-iso-PGF2α and interleukine IL-6 values also diminished after dietary intervention in the intervention group. Catalase activity increased significantly in the intervention group prior antioxidant supplementation. No significant differences were observed in other oxidative stress markers. Conclusions: The results suggest that diet and dietary supplements are involved in cell metabolism modulation and MS-related inflammatory processes. Consequently, low fat diets and antioxidant supplements may be used as complementary therapies for treatment of multiple sclerosis.
PB Arán
SN 0212-1611
LK https://hdl.handle.net/10612/19140
UL https://hdl.handle.net/10612/19140
NO Mauriz, E., Laliena, Vallejo, Tuñón, Rodríguez-López, Rodríguez-Pérez, & García-Fernández. (2013). Efecto de una dieta baja en grasas con suplementación de antioxidantes en los marcadores bioquímicos de residentes de larga estancia con esclerosis múltiple. Nutricion Hospitalaria, 28(6), 2229-2235. https://doi.org/10.3305/NH.2013.28.6.6983
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 07-jun-2024