RT info:eu-repo/semantics/article
T1 Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT)
A1 Arrazuria, Rakel
A1 Pérez Pérez, Valentín
A1 Molina, Elena
A1 Juste, Ramón A.
A1 Khafipour, Ehsan
A1 Elguezabal, Natalia
A2 Sanidad Animal
K1 Sanidad animal
K1 GALT
K1 Microbiota
K1 Rabbit gut
K1 3109 Ciencias Veterinarias
AB [EN] The gut associated lymphoid tissue (GALT) is the largest immune organ of the body. Although the gut transient and mucosa-associated microbiota have been largely studied, the microbiota that colonizes the GALT has received less attention. The gut microbiome plays an important role in competitive exclusion of pathogens and in development and maturation of immunity. Diet is a key factor affecting the microbiota composition in the digestive tract. To investigate the relation between diet, microbiota and GALT, microbial and cell composition of vermiform appendix (VA) and sacculus rotundus (SR) were studied in two groups of New Zealand white rabbits on different diets. Diet shifted the lymphoid tissue microbiota affecting the presence and/or absence of certain taxa and their abundances. Immunohistochemistry revealed that a higher fibre content diet resulted in M cell hyperplasia and an increase of recently recruited macrophages, whereas T-cell levels remained unaltered in animals on both high fibre and standard diets. These findings indicate that diet has an impact on the microbiota and cell composition of the GALT, which could act as an important microbial recognition site where interactions with beneficial bacteria can take place favouring microbiota replacement after digestive dysregulations
PB Nature Research
LK https://hdl.handle.net/10612/19349
UL https://hdl.handle.net/10612/19349
NO Arrazuria, R., Pérez, V., Molina, E., Juste, R. A., Khafipour, E., & Elguezabal, N. (2018). Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT). Scientific Reports, 8(1). https://doi.org/10.1038/S41598-018-32484-1
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 07-jun-2024